Zobrazeno 1 - 10
of 809
pro vyhledávání: '"allosteric inhibitors"'
Autor:
Eva M García-Cuesta, Pablo Martínez, Karthik Selvaraju, Gabriel Ulltjärn, Adrián Miguel Gómez Pozo, Gianluca D'Agostino, Sofia Gardeta, Adriana Quijada-Freire, Patricia Blanco Gabella, Carlos Roca, Daniel del Hoyo, Rodrigo Jiménez-Saiz, Alfonso García-Rubia, Blanca Soler Palacios, Pilar Lucas, Rosa Ayala-Bueno, Noelia Santander Acerete, Yolanda Carrasco, Carlos Oscar Sorzano, Ana Martinez, Nuria E Campillo, Lasse D Jensen, Jose Miguel Rodriguez Frade, César Santiago, Mario Mellado
Publikováno v:
eLife, Vol 13 (2024)
CXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development. Despite the potential the
Externí odkaz:
https://doaj.org/article/f6355c90de494368a3bd46842c4d4614
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractAbnormal accumulation of branched-chain amino acids (BCAAs) can lead to metabolic diseases and cancers. Branched-chain α-keto acid dehydrogenase kinase (BCKDK) is a key negative regulator of BCAA catabolism, and targeting BCKDK provides a pr
Externí odkaz:
https://doaj.org/article/25b42912963b48479ae5338a0038c07a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 239-245 (2023)
EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most attractive approaches to design
Externí odkaz:
https://doaj.org/article/25d2bf8ec18e40be90168dfa859cc71c
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 13, Iss 4, Pp 688-700 (2023)
Glycogen synthase kinase-3 (GSK-3) was discovered to be a multifunctional enzyme involved in a wide variety of biological processes, including early embryo formation, oncogenesis, as well cell death in neurodegenerative diseases. Several critical cel
Externí odkaz:
https://doaj.org/article/45825299790844659104d13b4fae9c28
Autor:
Jyoti Verma, Harish Vashisth
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5368 (2024)
The allosteric inhibition of insulin-like growth factor receptor 1 kinase (IGF1RK) is a potential strategy to overcome selectivity barriers for targeting receptor tyrosine kinases. We constructed structural models of a series of 12 indole-butyl-amine
Externí odkaz:
https://doaj.org/article/3785246f442145abb4c76f35fd8f1861
Autor:
Xuan-De Zhu, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Fen-Er Chen
Publikováno v:
Molecules, Vol 29, Iss 9, p 2120 (2024)
Ribonuclease H (RNase H) was identified as an important target for HIV therapy. Currently, no RNase H inhibitors have reached clinical status. Herein, a series of novel thiazolone[3,2-a]pyrimidine-containing RNase H inhibitors were developed, based o
Externí odkaz:
https://doaj.org/article/4d4f54ff0ff54589865da65fa7714578
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4376 (2024)
In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available
Externí odkaz:
https://doaj.org/article/02dd1e9bb55642adbf7c0688e96c50b6
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115440- (2023)
The discovery of new therapeutic strategies for diseases is essential for drug research. Deoxyhypusine synthase (DHPS) is a critical enzyme that modifies the conversion of the eukaryotic translation initiation factor 5A (eIF5A) precursor into physiol
Externí odkaz:
https://doaj.org/article/28fbe7a8c57447aeb6b55c2c33845213
Autor:
Conrad Fischer, Jenson R. Feys
Publikováno v:
Future Pharmacology, Vol 3, Iss 1, Pp 80-107 (2023)
While the COVID-19 pandemic seems to be on its decline, the unclear impacts of long-COVID cases, breakthrough infections in immunocompromised individuals, vaccine hesitancy, and inhomogeneous health-care accessibility constitute a not to be underesti
Externí odkaz:
https://doaj.org/article/0da92e08b1a248a29d0ad51dadd247c4