Zobrazeno 1 - 10
of 500
pro vyhledávání: '"allosteric activation"'
Autor:
Johannes Paladini, Annalena Maier, Judith Maria Habazettl, Ines Hertel, Rajesh Sonti, Stephan Grzesiek
Publikováno v:
eLife, Vol 12 (2024)
Abelson tyrosine kinase (Abl) is regulated by the arrangement of its regulatory core, consisting sequentially of the SH3, SH2, and kinase (KD) domains, where an assembled or disassembled core corresponds to low or high kinase activity, respectively.
Externí odkaz:
https://doaj.org/article/ef746d7d048644ea99ceb28b7e3f3eec
Autor:
Oreste Acuto
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Major Histocompatibility Complex (MHC) I and II and the αβ T-cell antigen receptor (TCRαβ) govern fundamental traits of adaptive immunity. They form a membrane-borne ligand-receptor system weighing host proteome integrity to detect contamination
Externí odkaz:
https://doaj.org/article/b7a4e3fec5d44804b62741f48fe5f0ac
Autor:
Fraydoon Rastinejad
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a multi-faceted nuclear receptor responsible for governing the development and proper functioning of liver and pancreatic islet cells. Its transcriptional functions encompass the regulation of vital metab
Externí odkaz:
https://doaj.org/article/16a20076b3774edf8eca3aa0bbcfdc27
Akademický článek
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Autor:
Zhuo Yang, Xiao‐Wen Zhang, Fang‐Fang Zhuo, Ting‐Ting Liu, Qian‐Wei Luo, Yong‐Zhe Zheng, Ling Li, Heng Yang, Yi‐Chi Zhang, Yan‐Hang Wang, Dan Liu, Peng‐Fei Tu, Ke‐Wu Zeng
Publikováno v:
Advanced Science, Vol 10, Iss 18, Pp n/a-n/a (2023)
Abstract Osteoblasts play an important role in the regulation of bone homeostasis throughout life. Thus, the damage of osteoblasts can lead to serious skeletal diseases, highlighting the urgent need for novel pharmacological targets. This study intro
Externí odkaz:
https://doaj.org/article/af3072ffab864901936da7ce3f47a1f0
Publikováno v:
Cells, Vol 12, Iss 15, p 1977 (2023)
CD40L is expressed in activated T cells, and it plays a major role in immune response and is a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a congenital functional defect in CD40L/CD40 signaling due to defective CD40
Externí odkaz:
https://doaj.org/article/575bdfa973794c68b30f549c3a8540ed
Autor:
Fengyu Cheng, Nan Wang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Inflammasomes are cytoplasmic complexes that form in response to exogenous microbial invasions and endogenous damage signals. Among the known inflammasomes, the activation of the NACHT (NAIP, CIITA, HET-E, and TP1 domain), leucine-rich repeat, and py
Externí odkaz:
https://doaj.org/article/5ea7524077cb44cb9e507e106d07172f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Gulsevin, Alican, Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Jin, Aihua H., Vetter, Irina, Meiler, Jens
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR. Although MrIC has no activating effect on α7 nAChR
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A85379
https://ul.qucosa.de/api/qucosa%3A85379/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A85379/attachment/ATT-0/
Autor:
Mondal, Dibyendu, Warshel, Arieh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Mar . 115(13), 3386-3391.
Externí odkaz:
https://www.jstor.org/stable/26508236