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Akademický článek

Computational nanochemistry study of the alisporivir and cyclosporin antimicrobial peptides through conceptual DFT-based computational peptidology and pharmacokinetics

Autor: Norma Flores-Holguín, Juan Frau, Daniel Glossman-Mitnik

Publikováno v: Mundo Nano, Vol 15, Iss 29 (2022)

This paper reports the results of a computational nanochemistry study of the chemical reactivities and bioactivity properties of two antimicrobial peptides using a CDFT-based computational peptidology (CDFT-CP) methodology, which is derived from the

Externí odkaz: https://doaj.org/article/5efe8e458b264394b6b962ed6c9b5a97

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Akademický článek

Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus

Autor: Konstantin N. Belosludtsev, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Mikhail V. Dubinin, Natalia V. Belosludtseva

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 17, p 9524 (2021)

Diabetes mellitus is a systemic metabolic disorder associated with mitochondrial dysfunction, with mitochondrial permeability transition (MPT) pore opening being recognized as one of its pathogenic mechanisms. Alisporivir has been recently identified

Externí odkaz: https://doaj.org/article/2240c3fe4ea2416d8c4a88e9b74e815f

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Akademický článek

Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx Mice

Autor: Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Dmitriy A. Serov, Kirill S. Tenkov, Evgeniya V. Belosludtseva, Konstantin N. Belosludtsev

Publikováno v: Biomedicines, Vol 9, Iss 9, p 1232 (2021)

Supporting mitochondrial function is one of the therapeutic strategies that improve the functioning of skeletal muscle in Duchenne muscular dystrophy (DMD). In this work, we studied the effect of a non-immunosuppressive inhibitor of mitochondrial per

Externí odkaz: https://doaj.org/article/90bf5ed0c55b42fdb20432e7711682a8

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Akademický článek

Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis

Autor: Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Konstantin N. Belosludtsev

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 18, p 9780 (2021)

Mitigation of calcium-dependent destruction of skeletal muscle mitochondria is considered as a promising adjunctive therapy in Duchenne muscular dystrophy (DMD). In this work, we study the effect of intraperitoneal administration of a non-immunosuppr

Externí odkaz: https://doaj.org/article/c18092804e4548ed87b446f47da43662

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Akademický článek

Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic Mice

Autor: Natalia V. Belosludtseva, Vlada S. Starinets, Irina B. Mikheeva, Dmitriy A. Serov, Maxim E. Astashev, Maxim N. Belosludtsev, Mikhail V. Dubinin, Konstantin N. Belosludtsev

Publikováno v: Biology, Vol 10, Iss 9, p 839 (2021)

Diabetes mellitus is a systemic metabolic disorder associated with mitochondrial dysfunction, with the mitochondrial permeability transition (MPT) pore opening being considered as one of its possible mechanisms. The effect of alisporivir, a non-immun

Externí odkaz: https://doaj.org/article/39fa45331609456cad8c92de7f901bc5

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Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus

Autor: Vlada S. Starinets, I. B. Mikheeva, Eugeny Yu. Talanov, Konstantin N. Belosludtsev, Natalia V. Belosludtseva, Mikhail V. Dubinin

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9524, p 9524 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81bd4ee9b208cc0a724b209712effa1
https://www.mdpi.com/1422-0067/22/17/9524

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Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic Mice

Autor: Konstantin N. Belosludtsev, Natalia V. Belosludtseva, Maxim E. Astashev, Mikhail V. Dubinin, Dmitriy A. Serov, Maxim N. Belosludtsev, I. B. Mikheeva, Vlada S. Starinets

Publikováno v: Biology, Vol 10, Iss 839, p 839 (2021)
Biology
Volume 10
Issue 9

Simple Summary Diabetes mellitus as a systemic metabolic disease is one of the most serious threats to global health in this century. Diabetic cardiomyopathy is increasingly recognized as one of the most important complications of the disease, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75bd09515c18c1e024a5c8d2a905320
https://www.mdpi.com/2079-7737/10/9/839

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Akademický článek

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

Autor: Brigitte Rosenwirth, Jean-Maurice Dumont, Grégoire Vuagniaux, Michael D. Bobardt, Philippe A. Gallay, Roger G. Ptak

Publikováno v: Viruses, Vol 5, Iss 3, Pp 981-997 (2013)

DEB025 (alisporivir) is a synthetic cyclosporine with inhibitory activity against human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV). It binds to cyclophilin A (CypA) and blocks essential functions of CypA in the viral replicatio

Externí odkaz: https://doaj.org/article/2482db037e7b462e9f372e0cb101db58

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