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SY26-3FROM ETHANOL TO SALSOLINOL: ROLE OF METABOLISM IN THE EFFECTS OF ETHANOL

Autor: Ezio Carboni, Miriam Melis, Michela Rosas, Alessandra Tiziana Peana, Pierluigi Caboni, Elio Maria Gioachino Acquas, Liliana Spina

Publikováno v: Alcohol and Alcoholism. 50:i29.3-i29

The role of acetaldehyde in the effects of its parent compound, ethanol has gone a profound re-evaluation in the last five decades since the clinical observation that patients treated with antabuse, an aldehyde dehydrogenase inhibitor, could perceive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::170ead4641524b59f35e502b64f00f47
https://doi.org/10.1093/alcalc/agv076.107

In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate

Autor: P.J. van Bladeren, Nico P. E. Vermeulen, M. van Iersel, Jan N. M. Commandeur, J.H.T.M. Ploemen, L.W. Wormhoudt

Publikováno v: Ploemen, J P H T M, van Iersel, M, Wormhoudt, L W, Commandeur, J N M, Vermeulen, N P E & van Bladeren, P J 1996, ' In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate. ', Biochemical Pharmacology, vol. 52, pp. 197-204 . https://doi.org/10.1016/0006-2952(96)00142-6
Biochemical Pharmacology 52 (1996)
Biochemical Pharmacology, 52, 197-204
Biochemical Pharmacology, 2, 52, 197-204
Biochemical Pharmacology, 52, 197-204. Elsevier Inc.

The drug disulfiram (DSF, Antabuse) has been used in the therapy of alcohol abuse. It is a potent inhibitor of aldehyde dehydrogenase. Its reduced form, diethyldithiocarbamate (DDTC), and further metabolites show similar activities. DSF and DDTC have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1019d53dec0451bc9dd5ff4571a6233
https://research.vu.nl/en/publications/db901fc4-3409-471c-967d-6d4b148ab51a

Evidence against a biphasic effect of acetaldehyde on voluntary ethanol consumption in rats

Autor: Richard A. Deitrich, C.J.Peter Eriksson

Publikováno v: Pharmacology Biochemistry and Behavior. 13:291-296

A group of 27 male Long-Evans rats was given a 2 week period of free-choice ethanol and consumed 1.26 +/- 1.27 g/kg/day (mean +/- SD). The animals were then divided into 3 groups. One group received the aldehyde dehydrogenase inhibitor, cyanamide, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a39e6ee88bfa1e7a7a61aae154d2c6d
https://doi.org/10.1016/s0091-3057(80)80044-x

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