Zobrazeno 1 - 10
of 7 981
pro vyhledávání: '"airway smooth muscle"'
Autor:
Nilesh Sudhakar Ambhore, Premanand Balraj, Ashish Kumar, Mohammad Irshad Reza, Yogaraj S. Ramakrishnan, Jacob Tesch, Sahil Lohana, Venkatachalem Sathish
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of est
Externí odkaz:
https://doaj.org/article/1374b887534941a691c4103e49c319ef
Autor:
Sepide Behrouz, Arghavan Memarzia, Mohammad Hossein Eshaghi Ghalibaf, Mohammad Hossein Boskabady
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 10, Pp 1317-1322 (2024)
Objective(s): In the present study, the relaxant effect of crocetin on tracheal smooth muscle cells (TSM) and its possible mechanisms were evaluated.Materials and Methods: The study was conducted on 54 male Wistar rats in 8 groups. TSM was contracted
Externí odkaz:
https://doaj.org/article/af4d875161144690bf29f1e5e8eec129
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Understanding the characteristics of pulmonary resistance and elastance in relation to the location of airway narrowing, e.g., tracheal stenosis vs. intrapulmonary airway obstruction, will help us understand lung function characte
Externí odkaz:
https://doaj.org/article/727e34b7fcd24e23b643b9e35922883b
Autor:
Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Andrés Rojas-Ruiz, Liah Fereydoonzad, Percival Graham, Ynuk Bossé
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The level of airway constriction in thin slices of lung tissue is highly variable. Owing to the labor-intensive nature of these experiments, determining the number of airways to be analyzed in order to allocate a reliable value of constricti
Externí odkaz:
https://doaj.org/article/637cd8a18c8343308419698a40b24834
Autor:
Sanjana Mahadev Bhat, Gary C. Sieck
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 6, Pp 159-176 (2024)
Abstract Succinate dehydrogenase (SDH) is a key mitochondrial enzyme involved in the tricarboxylic acid cycle, where it facilitates the oxidation of succinate to fumarate, and is coupled to the reduction of ubiquinone in the electron transport chain
Externí odkaz:
https://doaj.org/article/8c3e988224004336823416fd64b1b4a3
Autor:
Jiaying Gu, Dengfeng Zhou
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Background Asthma is a respiratory disease characterized by airway remodeling. We aimed to find out the role and mechanism of lncRNA MEG3 in asthma. Methods We established a cellular model of asthma by inducing human airway smooth muscle cel
Externí odkaz:
https://doaj.org/article/90dcece3801f402a902c0a805b63b885
Autor:
J. Hanusrichterova, M. Kolomaznik, R. Barosova, J. Adamcakova, D. Mokra, J. Mokry, H. Skovierova, M. M. Kelly, E. deHeuvel, S. Wiehler, D. Proud, H. Shen, P. G. Mukherjee, M. W. Amrein, A. Calkovska
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The
Externí odkaz:
https://doaj.org/article/b61fa7c8da2044a69945f7d1fe1fe882
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Steroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD) presents a problem for controlling the chronic inflammation of the airways. The glucocorticoid receptor (GR) mediates the intracellular signaling of inhaled cor
Externí odkaz:
https://doaj.org/article/adb17ea1ebe842f28babc9b43b0b4db2
Autor:
Lingyu Pan, Bangfu He, Chunxia Gong, Yehong Sun, Xianchun Duan, Yanquan Han, Jijun Chu, Yongzhong Wang
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Yanghe Pingchuan decoction (YPD) has been used for asthma treatment for many years in China. We sought to understand the mechanism of YPD, and find more potential targets for YPD-based treatment of asthma. Methods An ovalbumin-ind
Externí odkaz:
https://doaj.org/article/da1cea067fe849d9bc5a2c0acf03db6d
Autor:
Yongfeng Luo, Ke Cao, Joanne Chiu, Hui Chen, Hong-Jun Wang, Matthew E Thornton, Brendan H Grubbs, Martin Kolb, Michael S Parmacek, Yuji Mishina, Wei Shi
Publikováno v:
eLife, Vol 12 (2024)
Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which developmenta
Externí odkaz:
https://doaj.org/article/310cc91eef7547f0b2c6ff8d0cb9222f