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Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

Autor: Paolo Casali, Tian Shen, Yijiang Xu, Zhifang Qiu, Daniel P. Chupp, John Im, Zhenming Xu, Hong Zan

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Estrogen contributes to females' strong antibody response to microbial vaccines and proneness to autoimmunity, particularly antibody-mediated systemic autoimmunity, in females. We have hypothesized that this is due to estrogen-mediated potentiation o

Externí odkaz: https://doaj.org/article/081b835f52e44e3a80823d824d407a34

HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells

Autor: Burkitkan Akbay, Diego Germini, Amangeldy K. Bissenbaev, Yana R. Musinova, Evgeny V. Sheval, Yegor Vassetzky, Svetlana Dokudovskaya

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 4, p 1588 (2021)

HIV-1 infects T cells, but the most frequent AIDS-related lymphomas are of B-cell origin. Molecular mechanisms of HIV-1-induced oncogenic transformation of B cells remain largely unknown. HIV-1 Tat protein may participate in this process by penetrati

Externí odkaz: https://doaj.org/article/8550d964d236436694c4ffe72a0485a8

Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report

Autor: Maria Pia Cicalese, Jolanda Gerosa, Manuela Baronio, Davide Montin, Francesco Licciardi, Annarosa Soresina, Rosa Maria Dellepiane, Maurizio Miano, Lucia Augusta Baselli, Stefano Volpi, Carlo Dufour, Alessandro Plebani, Alessandro Aiuti, Vassilios Lougaris, Georgia Fousteri

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Mutations in genes that control class switch recombination and somatic hypermutation during the germinal center (GC) response can cause diverse immune dysfunctions. In particular, mutations in CD40LG, CD40, AICDA, or UNG cause hyper-IgM (HIGM) syndro

Externí odkaz: https://doaj.org/article/d31e6288c914441486635ff1670779a9

The effects of vitamin A in B cells from patients with the immunodeficiency disorder CVID

Autor: Guttormsen, Ida

Publikováno v: Guttormsen, Ida. The effects of vitamin A in B cells from patients with the immunodeficiency disorder CVID. Master thesis, University of Oslo, 2018

Externí odkaz: http://hdl.handle.net/10852/63343
https://www.duo.uio.no/bitstream/handle/10852/63343/1/Master-thesis-Ida-Guttormsen.pdf