Zobrazeno 1 - 10
of 73
pro vyhledávání: '"agitoxin"'
Autor:
Alexandra L. Primak, Nikita A. Orlov, Steve Peigneur, Jan Tytgat, Anastasia A. Ignatova, Kristina R. Denisova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V. Feofanov
Publikováno v:
Toxins, Vol 15, Iss 3, p 229 (2023)
The growing interest in potassium channels as pharmacological targets has stimulated the development of their fluorescent ligands (including genetically encoded peptide toxins fused with fluorescent proteins) for analytical and imaging applications.
Externí odkaz:
https://doaj.org/article/98a6a2fd89be41559e83da7da2cff6be
Autor:
Kristina R. Denisova, Nikita A. Orlov, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexey V. Feofanov, Oksana V. Nekrasova
Publikováno v:
Bioengineering, Vol 9, Iss 7, p 295 (2022)
Fluorescently labeled peptide blockers of ion channels are useful probes in studying the localization and functioning of the channels and in the performance of a search for new channel ligands with bioengineering screening systems. Here, we report on
Externí odkaz:
https://doaj.org/article/fe12d2e85cd942369de5dcec0d938c27
Autor:
George V. Sharonov, Oksana V. Nekrasova, Ksenia S. Kudryashova, Mikhail P. Kirpichnikov, Alexey V. Feofanov
Publikováno v:
Bioengineering, Vol 8, Iss 11, p 187 (2021)
Screening drug candidates for their affinity and selectivity for a certain binding site is a crucial step in developing targeted therapy. Here, we created a screening assay for receptor binding that can be easily scaled up and automated for the high
Externí odkaz:
https://doaj.org/article/d16d354f7ef944c1a6ecd7667f7027b7
Autor:
Oksana V. Nekrasova, Alexandra L. Primak, Anastasia A. Ignatova, Valery N. Novoseletsky, Olga V. Geras’kina, Ksenia S. Kudryashova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexander S. Arseniev, Alexey V. Feofanov
Publikováno v:
Toxins, Vol 12, Iss 12, p 802 (2020)
Recently developed fluorescent protein-scorpion toxin chimeras (FP-Tx) show blocking activities for potassium voltage-gated channels of Kv1 family and retain almost fully pharmacological profiles of the parental peptide toxins (Kuzmenkov et al., Sci
Externí odkaz:
https://doaj.org/article/6c6e8f2d8c2143f7a9303d4be758b138
Akademický článek
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Autor:
Alexandra L Primak, Alexey V. Feofanov, V. N. Novoseletsky, S.A. Yakimov, Mikhail P. Kirpichnikov, Ksenia S Kudryashova, Oksana V. Nekrasova, Olga Geraskina, Alexander S. Arseniev, Anastasia A. Ignatova
Publikováno v:
Toxins
Toxins, Vol 12, Iss 802, p 802 (2020)
Volume 12
Issue 12
Toxins, Vol 12, Iss 802, p 802 (2020)
Volume 12
Issue 12
Recently developed fluorescent protein-scorpion toxin chimeras (FP-Tx) show blocking activities for potassium voltage-gated channels of Kv1 family and retain almost fully pharmacological profiles of the parental peptide toxins (Kuzmenkov et al., Sci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89a78511213443432af2b490e2134bc
http://europepmc.org/articles/PMC7766132
http://europepmc.org/articles/PMC7766132
Autor:
Ksenia S. Kudryashova, George V. Sharonov, Oksana V. Nekrasova, Mikhail P. Kirpichnikov, Alexey V. Feofanov
Publikováno v:
Bioengineering, Vol 8, Iss 187, p 187 (2021)
Bioengineering
Volume 8
Issue 11
Bioengineering
Volume 8
Issue 11
Screening drug candidates for their affinity and selectivity for a certain binding site is a crucial step in developing targeted therapy. Here, we created a screening assay for receptor binding that can be easily scaled up and automated for the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb244e4f8202f10ad63f334d2d9bdf73
https://www.mdpi.com/2306-5354/8/11/187
https://www.mdpi.com/2306-5354/8/11/187
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Moscow University Biological Sciences Bulletin. 72:25-29
The Kv1.3 voltage-gated potassium channel is involved in a number of processes in excitable and nonexcitable cells: maintenance of resting membrane potential, signal transduction, apoptosis, regulation of cell volume, activation and proliferation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef9fe001102b023787a1b19f7b36895
https://doi.org/10.3103/s0096392517010060
https://doi.org/10.3103/s0096392517010060