Zobrazeno 1 - 10
of 8 733
pro vyhledávání: '"aggrecan)"'
Autor:
Shan Gao, Menglong Jia, Jingwei Wang, Qiankun Sun, Fangxiu Liu, Longtan Yu, YanXing Guo, Nianhu Li, Lei Wei
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Osteoarthritis (OA) is the most prevalent type of arthritis and the main reason for progressive disability in middle-aged and older people. Studies of candidate genes may provide a novel insight and treatment strategy for knee ost
Externí odkaz:
https://doaj.org/article/b03e3e50a6174f198b1a09d20fcb4bea
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106614- (2024)
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a tri
Externí odkaz:
https://doaj.org/article/9b188baf16d24c7cb9c3cb629ea735bb
Autor:
Hanan M. Hassan, Ahmed M. Hamdan, Abdullah Alattar, Reem Alshaman, Omar Bahattab, Mohammed M. H. Al-Gayyar
Publikováno v:
Redox Report, Vol 29, Iss 1 (2024)
Emodin is a naturally occurring anthraquinone derivative with a wide range of pharmacological activities, including neuroprotective and anti-inflammatory activities. We aim to assess the anticancer activity of emodin against hepatocellular carcinoma
Externí odkaz:
https://doaj.org/article/8ad333485c1a416587f4d2f5edf12c6a
Akademický článek
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Autor:
Peter M. van der Kraan, Arjan P.M. van Caam, Esmeralda N. Blaney Davidson, Martijn H.J. van den Bosch, Fons A.J. van de Loo
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100459- (2024)
Introduction: Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines this function is the large aggregating proteoglycan of cartilage, aggrecan. Aggr
Externí odkaz:
https://doaj.org/article/b72967b90e8945799f4440402ffa7eae
Autor:
Mei-Feng Chen, Chih-Chien Hu, Yung-Heng Hsu, Yu-Chih Lin, Kai-Lin Chen, Steve W. N. Ueng, Yuhan Chang
Publikováno v:
Bone & Joint Research, Vol 12, Iss 12, Pp 734-746 (2023)
Aims: Therapeutic agents that prevent chondrocyte loss, extracellular matrix (ECM) degradation, and osteoarthritis (OA) progression are required. The expression level of epidermal growth factor (EGF)-like repeats and discoidin I-like domains-containi
Externí odkaz:
https://doaj.org/article/7e8478f292414154b57787160e8b5a6a
Autor:
Chiara Gramegna Tota, Alessandra Leone, Asifa Khan, Antonella Forlino, Antonio Rossi, Chiara Paganini
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1064 (2024)
Desbuquois dysplasia type 1 (DBQD1) is a recessive chondrodysplasia caused by mutations in the CANT1 gene, encoding for the Golgi Calcium-Activated Nucleotidase 1 (CANT1). The enzyme hydrolyzes UDP, the by-product of glycosyltransferase reactions, bu
Externí odkaz:
https://doaj.org/article/d9c90a9e00354b30b7298d5b36892585
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Objective To characterize the phenotype spectrum, diagnosis, and response to growth‐promoting therapy in patients with ACAN variants causing familial short stature. Methods Three families with ACAN variants causing short stature were repor
Externí odkaz:
https://doaj.org/article/2d66a09de1d64d4788bdf434211a8176
Autor:
Daniel H. Zimmerman, Zoltan Szekanecz, Adrienn Markovics, Kenneth S. Rosenthal, Roy E. Carambula, Katalin Mikecz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Rheumatoid arthritis (RA) is recognized as an autoimmune joint disease driven by T cell responses to self (or modified self or microbial mimic) antigens that trigger and aggravate the inflammatory condition. Newer treatments of RA employ monoclonal a
Externí odkaz:
https://doaj.org/article/e4aec4b93f5348f99a094ae2c4a12b9e
Autor:
Sumito Dateki1 sdateki1@nagasaki-u.ac.jp
Publikováno v:
Clinical Pediatric Endocrinology. 2017, Vol. 26 Issue 3, p119-125. 7p. 1 Black and White Photograph, 1 Diagram, 1 Chart.