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Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK–SIRT1–PGC1a energy metabolism pathway

Autor: Zhijia Guo, Meng Wang, Xiaodong Ying, Jiyu Yuan, Chenggang Wang, Wenjie Zhang, Shouyuan Tian, Xiaoyan Yan

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract A large number of data suggest that caloric restriction (CR) has a protective effect on myocardial ischemia/reperfusion injury (I/R) in the elderly. However, the mechanism is still unclear. In this study, we created the I/R model in vivo by

Externí odkaz: https://doaj.org/article/0479f51f76f04278ade24da502deb471

Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart

Autor: Bou-Teen, Diana, Kaludercic, Nina, Weissman, David, Turan, Belma, Maack, Christoph, Di Lisa, Fabio, Ruiz-Meana, Marisol

Publikováno v: In Free Radical Biology and Medicine 1 May 2021 167:109-124

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Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.

Autor: Mone P; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy., Agyapong ED; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy., Morciano G; Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.; Maria Cecilia Hospital, GVM Care & Research, Cotignola 48033, Italy., Jankauskas SS; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA., De Luca A; Department of Mental and Physical Health and Preventive Medicine, Vanvitelli University, Naples 80100, Italy., Varzideh F; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA., Pinton P; Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.; Maria Cecilia Hospital, GVM Care & Research, Cotignola 48033, Italy., Santulli G; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy.; Department of Advanced Biomedical Sciences, 'Federico II' University, International Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Naples 80131, Italy.; Department of Molecular Pharmacology, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY 10461, USA.

Publikováno v: The journal of cardiovascular aging [J Cardiovasc Aging] 2024 Apr; Vol. 4 (2). Date of Electronic Publication: 2024 Feb 01.