Zobrazeno 1 - 10
of 320
pro vyhledávání: '"african sleeping sickness"'
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background Gambiense human African trypanosomiasis (gHAT) has been brought under control recently with village-based active screening playing a major role in case reduction. In the approach to elimination, we investigate how to optimise acti
Externí odkaz:
https://doaj.org/article/993ff2081b384bd8804b9ca504ffc7b8
Akademický článek
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Autor:
Xinyu Wang, Qiaoling Ruan, Wen-Hong Zhang, Jianfei Gu, Yiyi Qian, Muxin Chen, Qin Liu, Qing Lu, Wenhong Zhang
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 2, Pp 400-404 (2018)
Human African trypanosomiasis is endemic to parts of sub-Saharan Africa and should be considered in the differential diagnosis of patients who have visited or lived in Africa. We report a 2017 case of stage 2 Trypanosoma brucei gambiense disease in a
Externí odkaz:
https://doaj.org/article/b9b4b7467a5e4ad3a523c65a883c6ece
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 42 (2020)
In the early 20th century, a series of epidemics across equatorial Africa brought African sleeping sickness (human African trypanosomiasis, HAT) to the attention of the European colonial administrations. This disease presented an exciting challenge f
Externí odkaz:
https://doaj.org/article/d350a7337ee34389a7ba06695e268ed8
Autor:
Jessica A. Engel, Amy J. Jones, Vicky M. Avery, Subathdrage D.M. Sumanadasa, Susanna S. Ng, David P. Fairlie, Tina S. Adams, Katherine T. Andrews
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 117-126 (2015)
Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as we
Externí odkaz:
https://doaj.org/article/3b5a96dffd4a4357a8627fdda04672cf
Autor:
Conrad L. Epting, Brian T. Emmer, Nga Y. Du, Joann M. Taylor, Ming Y. Makanji, Cheryl L. Olson, David M. Engman
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT African trypanosomiasis is caused by infection with the protozoan parasite Trypanosoma brucei. During infection, this pathogen divides rapidly to high density in the bloodstream of its mammalian host in a manner similar to that of leukemia.
Externí odkaz:
https://doaj.org/article/31d7a561c496421a96c0f83003ea87a1
Autor:
Annika Wagner, Johannes C. B. Dietschreit, Bernd Engels, Ute A. Hellmich, Hermann Schindelin, Christian Ochsenfeld, T. Anh Le, Till Opatz, Philipp Klein
Publikováno v:
Angewandte Chemie (International Ed. in English)
The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12ffbeb4137d89e9aac261aebfde156
http://europepmc.org/articles/PMC7496126
http://europepmc.org/articles/PMC7496126
Publikováno v:
Medical Sciences, Vol 6, Iss 1, p 12 (2018)
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essentia
Externí odkaz:
https://doaj.org/article/0df36a2ec2774054810905ad6234350e
Autor:
Kotlyar Simon
Publikováno v:
Journal of Global Infectious Diseases, Vol 2, Iss 1, Pp 43-48 (2010)
East African sleeping sickness, caused by Trypanosoma brucei rhodesiense, is prominent in Uganda and poses a serious public health challenge in the region. This publication attempts to provide key components for designing a strategy for a nationwide
Externí odkaz:
https://doaj.org/article/9b63db90866347fabbf36fabd865e794
Autor:
Simon Kotlyar
Publikováno v:
Journal of Global Infectious Diseases, Vol 2, Iss 1, Pp 43-48 (2010)
East African sleeping sickness, caused by Trypanosoma brucei rhodesiense, is prominent in Uganda and poses a serious public health challenge in the region. This publication attempts to provide key components for designing a strategy for a nationwide
Externí odkaz:
https://doaj.org/article/bb7f6053d524488c90599e1b77be4011