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Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells

Autor: Pierre Cheung, Julia Thorngren, Bo Zhang, Svitlana Vasylovska, Francesco Lechi, Jonas Persson, Stefan Ståhl, John Löfblom, Olle Korsgren, Jonas Eriksson, Joey Lau, Olof Eriksson

Publikováno v: EJNMMI Research, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Background Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages of donor tissue and the need

Externí odkaz: https://doaj.org/article/9bc788183687432ebdda01b90d26bed0

Radionuclide Therapy of HER2-Expressing Xenografts Using [ 177 Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab.

Autor: Liu, Yongsheng¹ (AUTHOR) yongsheng.liu@igp.uu.se, Xu, Tianqi¹ (AUTHOR) tianqi.xu@igp.uu.se, Vorobyeva, Anzhelika¹ (AUTHOR) anzhelika.vorobyeva@igp.uu.se, Loftenius, Annika² (AUTHOR) annika.loftenius@affibody.se, Bodenko, Vitalina³ (AUTHOR) bodenkovitalina@gmail.com, Orlova, Anna⁴ (AUTHOR) anna.orlova@ilk.uu.se, Frejd, Fredrik Y.^1,2 (AUTHOR) fredrik.frejd@affibody.se, Tolmachev, Vladimir^1,3 (AUTHOR) vladimir.tolmachev@igp.uu.se

Publikováno v: Cancers. May2023, Vol. 15 Issue 9, p2409. 15p.

Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β.

Autor: Wegrzyniak, Olivia¹ (AUTHOR), Zhang, Bo¹ (AUTHOR), Rokka, Johanna² (AUTHOR), Rosestedt, Maria¹ (AUTHOR), Mitran, Bogdan^1,3 (AUTHOR), Cheung, Pierre¹ (AUTHOR), Puuvuori, Emmi¹ (AUTHOR), Ingvast, Sofie² (AUTHOR), Persson, Jonas^1,4 (AUTHOR), Nordström, Helena⁵ (AUTHOR), Löfblom, John⁴ (AUTHOR), Pontén, Fredrik² (AUTHOR), Frejd, Fredrik Y.^2,6 (AUTHOR), Korsgren, Olle² (AUTHOR), Eriksson, Jonas^1,7 (AUTHOR) jonas.p.eriksson@akademiska.se, Eriksson, Olof^1,3 (AUTHOR) olof.eriksson@ilk.uu.se

Publikováno v: EJNMMI Radiopharmacy & Chemistry. 9/21/2023, Vol. 8 Issue 1, p1-18. 18p.

Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile.

Autor: Liu, Yongsheng¹ (AUTHOR), Oroujeni, Maryam^1,2 (AUTHOR), Liao, Yunqi¹ (AUTHOR), Vorobyeva, Anzhelika¹ (AUTHOR), Bodenko, Vitalina¹ (AUTHOR), Orlova, Anna³ (AUTHOR), Konijnenberg, Mark⁴ (AUTHOR), Carlqvist, Matilda² (AUTHOR), Wahlberg, Elisabet² (AUTHOR), Loftenius, Annika² (AUTHOR), Frejd, Fredrik Y^1,2 (AUTHOR), Tolmachev, Vladimir¹ (AUTHOR) vladimir.tolmachev@igp.uu.se

Publikováno v: European Journal of Nuclear Medicine & Molecular Imaging. Nov2024, Vol. 51 Issue 13, p4038-4048. 11p.