Zobrazeno 1 - 2
of 2
pro vyhledávání: '"adverse effects [Amyloid beta-Peptides]"'
Autor:
Manuel Mittag, Jens Wagner, Martin K. Schwarz, Martin Fuhrmann, Julia Steffen, Stefanie Poll, Boris Schmidt, Inna Schwarz, Hans-Rüdiger Geis, Stefan Remy, Lena C. Schmid
Publikováno v:
Neuron 92(1), 114-125 (2016). doi:10.1016/j.neuron.2016.08.034
Alzheimer's disease (AD) is characterized by cognitive decline and neuronal network dysfunction, but the underlying mechanisms remain unknown. In the hippocampus, microcircuit activity during learning and memory processes is tightly controlled by O-L
Publikováno v:
Neurobiology of aging 40, 98-102 (2016). doi:10.1016/j.neurobiolaging.2016.01.008
Soluble forms of oligomeric amyloid beta (AβO) are involved in the loss of synaptic plasticity and memory, especially in early phases of Alzheimer's disease. Stimulation of dopamine D1/D5 receptors (D1R/D5R) is known to increase surface expression o