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Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury.

Autor: Ye G; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China., Wang Z; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Pudong New Area, Shanghai 200120, China., Chen P; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China., Ye J; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China., Li S; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China., Chen M; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China., Feng J; Department of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China., Wang H; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China., Chen W; Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University. Ningbo 315040, Zhejiang, China; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Pudong New Area, Shanghai 200120, China. Electronic address: lhlchenwei@nbu.edu.cn.

Publikováno v: Neuroscience [Neuroscience] 2024 Nov 28; Vol. 565, pp. 1-9. Date of Electronic Publication: 2024 Nov 28.

Assessing mRNA translation in mouse adult microglia and bone-marrow-derived macrophages

Autor: Ignazio Antignano, Lily Keane, Melania Capasso

Publikováno v: STAR Protocols, Vol 4, Iss 4, Pp 102559- (2023)

Summary: Protein synthesis, or mRNA translation, is the biological process through which genetic information stored in messenger RNAs is encoded into proteins. Here, we present an optimized protocol for assessing the translation rate in mouse adult m

Externí odkaz: https://doaj.org/article/8c98f1f6414541d39a06571907cf0bfe

Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase

Autor: Wulin Tan, Po-Yi Paul Su, Jacqueline Leff, Xiang Gao, Jiao Chen, Andrew K. Guan, Gokul Kalyanasundaram, Averil Ma, Zhonghui Guan

Publikováno v: Cell Discovery, Vol 8, Iss 1, Pp 1-18 (2022)

Abstract Microgliosis is a hallmark of many neurological diseases, including Alzheimer’s disease, stroke, seizure, traumatic brain and spinal cord injuries, and peripheral and optic nerve injuries. Recent studies have shown that the newly self-rene

Externí odkaz: https://doaj.org/article/3ee10d3f7c3b466ca20ce8a7864f40f2

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