Zobrazeno 1 - 10
of 54
pro vyhledávání: '"adoptive t cell therapies"'
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-30 (2024)
Abstract Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, its limited durability often results in primary resistance. High-throughput screening technologies, which include both ge
Externí odkaz:
https://doaj.org/article/bedbc000af50411f9315fd5d66600049
Autor:
Arya Afsahi, Christopher M. Silvestri, Allyson E. Moore, Carly F. Graham, Kaylyn Bacchiochi, Martine St-Jean, Christopher L. Baker, Robert G. Korneluk, Shawn T. Beug, Eric C. LaCasse, Jonathan L. Bramson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe genesis of SMAC mimetic drugs is founded on the observation that many cancers amplify IAP proteins to facilitate their survival, and therefore removal of these pathways would re-sensitize the cells towards apoptosis. It has become incre
Externí odkaz:
https://doaj.org/article/eb5ca895b54b482fb6cf4a6da61045ce
Autor:
Lien De Beck, Robin Maximilian Awad, Veronica Basso, Noelia Casares, Kirsten De Ridder, Yannick De Vlaeminck, Alessandra Gnata, Cleo Goyvaerts, Quentin Lecocq, Edurne San José-Enériz, Stefaan Verhulst, Ken Maes, Karin Vanderkerken, Xabier Agirre, Felipe Prosper, Juan José Lasarte, Anna Mondino, Karine Breckpot
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy has improved the treatment of malignant skin cancer of the melanoma type, yet overall clinical response rates remain low. Combination therapies could be key to meet this cogent medical need. Because epigenetic hallmarks represent promis
Externí odkaz:
https://doaj.org/article/f6044c9296d648419688c29e75e4e1a4
Autor:
Christopher Kressler, Gilles Gasparoni, Karl Nordström, Dania Hamo, Abdulrahman Salhab, Christoforos Dimitropoulos, Sascha Tierling, Petra Reinke, Hans-Dieter Volk, Jörn Walter, Alf Hamann, Julia K. Polansky
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
CD4+ regulatory T cells (Tregs) are key mediators of immunological tolerance and promising effector cells for immuno-suppressive adoptive cellular therapy to fight autoimmunity and chronic inflammation. Their functional stability is critical for thei
Externí odkaz:
https://doaj.org/article/d2ea104a2f8548089bd9d3526367794e
Akademický článek
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Akademický článek
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Autor:
Bu-Nam Jeon, Hye-Ran Kim, Yun Shin Chung, Bo-Ra Na, Hyunkyung Park, Chorong Hong, Yasmin Fatima, Hyeonju Oh, Chang-Hyun Kim, Chang-Duk Jun
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
Correct temporal and spatial control of actin dynamics is essential for the cytotoxic T cell effector function against tumor cells. However, little is known whether actin engineering in tumor-targeted T cells can enhance their antitumor responses, th
Externí odkaz:
https://doaj.org/article/6daf097227694acc81269f7b0202ca5d
Autor:
Yao Wang, Meixia Chen, Zhiqiang Wu, Chuan Tong, Hanren Dai, Yelei Guo, Yang Liu, Jianhua Huang, Haiyan Lv, Can Luo, Kai-chao Feng, Qing-ming Yang, Xiao-lei Li, Weidong Han
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
Expressed by cancer stem cells of various epithelial cell origins, CD133 is an attractive therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed CD133 (CART-133) was first tested in this trial. The anti-tumor sp
Externí odkaz:
https://doaj.org/article/f3e7c9850ad74bd1afb8b2aa4cd9e521
Autor:
V. Cervera-Carrascon, M. Siurala, J. M. Santos, R. Havunen, S. Tähtinen, P. Karell, S. Sorsa, A. Kanerva, A. Hemminki
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
Releasing the patient's immune system against their own malignancy by the use of checkpoint inhibitors is delivering promising results. However, only a subset of patients currently benefit from them. One major limitation of these therapies relates to
Externí odkaz:
https://doaj.org/article/d89957be564a46b29a243aac324e3904
Akademický článek
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