Zobrazeno 1 - 10
of 8 169
pro vyhledávání: '"admet"'
Autor:
Amir Raza, Jitendra Chaudhary, Azmat Ali Khan, Mahaveer Singh, Deepak Kumar, Abdul Malik, Pankaj Wadhwa
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Background Neurodegenerative disorders (NDs), primarily affecting the elderly, are marked by complex pathophysiological processes and are projected to become the second leading cause of death. Parkinson’s disease (PD), one of the most comm
Externí odkaz:
https://doaj.org/article/01756644a09c4c099136acb9b3387d68
Autor:
Ranjan K. Mohapatra, Ahmed Mahal, Pranab K. Mohapatra, Ashish K. Sarangi, Snehasish Mishra, Meshari A. Alsuwat, Nada N. Alshehri, Sozan M. Abdelkhalig, Mohammed Garout, Mohammed Aljeldah, Ahmad A. Alshehri, Ahmed Saif, Mohammed Abdulrahman Alshahrani, Ali S. Alqahtani, Yahya A. Almutawif, Hamza M.A. Eid, Faisal M Albaqami, Mohnad Abdalla, Ali A. Rabaan
Publikováno v:
Journal of Biosafety and Biosecurity, Vol 6, Iss 3, Pp 157-169 (2024)
Outbreaks of Monkeypox (mpox) in over 100 non-endemic countries in 2022 represented a serious global health concern. Once a neglected disease, mpox has become a global public health issue. A42R profilin-like protein from mpox (PDB ID: 4QWO) represent
Externí odkaz:
https://doaj.org/article/e09969d4fc4745c680694137549a0ecc
Autor:
Sevtap Caglar Yavuz
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract In this study, two new molecules were synthesized from the reaction of 2-methyl-1H-benzo[d]imidazole with aryl halides in the presence of a strong base. The structures newly of synthesized 1,2-disubstituted benzimidazole compounds were chara
Externí odkaz:
https://doaj.org/article/b339aacbf5064cc384d9df1b1efa9dd4
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Background: Drug discovery and development is the extremely costly and time-consuming process of identifying new molecules that can interact with a biomarker target to interrupt the disease pathway of interest. In addition to binding the tar
Externí odkaz:
https://doaj.org/article/13404294b3e3481a9863b450b88f3463
Autor:
Dhananjay Singh, Nishu Mittal, Pooja Mittal, Neeraj Tiwari, Salah Ud-Din Khan, Mohamed A. M. Ali, Anis Ahmad Chaudhary, Mohammed Haris Siddiqui
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Rhinoviruses (RVs) cause upper respiratory tract infections and pneumonia in children and adults. These non-enveloped viruses contain viral coats of four capsid proteins: VP1, VP2, VP3, and VP4. The canyon on VP1 used cell surface receptor I
Externí odkaz:
https://doaj.org/article/538d2531da9147f2b12df7e15f7e3f6a
Autor:
Areeba Akram, Azra Sakhawat, Muhammad Usman Ghani, Muhammad Umer Khan, Raima Rehman, Qurban Ali, Peng Jin-liang, Daoud Ali
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Cystic Fibrosis Transmembrane Regulator (CFTR) is a significant protein that is responsible for the movement of ions across cell membranes. The cystic fibrosis (CF) occur due to the mutations in the CFTR gene as it produces the dysfunctional
Externí odkaz:
https://doaj.org/article/3e115058162e4d33b1715c471ef6b5f6
Autor:
Mohamed Moussaoui, Soukayna Baammi, Hatim Soufi, Mouna Baassi, Achraf El Allali, M. E. Belghiti, Rachid Daoud, Said Belaaouad
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Breast cancer remains a leading cause of cancer-related deaths among women globally, necessitating the development of more effective therapeutic agents with minimal side effects. This study explores novel 1,2,4-triazine-3(2H)-one derivatives
Externí odkaz:
https://doaj.org/article/7dcad3fc9b42434f92c49d2e8b09360f
Autor:
Sapan K. Shah, Dinesh R. Chaple, Vijay H. Masand, Rahul D. Jawarkar, Somdatta Chaudhari, A. Abiramasundari, Magdi E. A. Zaki, Sami A. Al-Hussain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-27 (2024)
Abstract Cardiovascular diseases, including heart failure, stroke, and hypertension, affect 608 million people worldwide and cause 32% of deaths. Combination therapy is required in 60% of patients, involving concurrent Renin–Angiotensin–Aldostero
Externí odkaz:
https://doaj.org/article/2b5f474d52824d43937c15b8396ae1cd
Autor:
Basiru Olaitan Ajiboye, Toluwase Hezekiah Fatoki, Olamilekan Ganiu Akinola, Kazeem Olasunkanmi Ajeigbe, Abraham Fisayo Bamisaye, Eva-María Domínguez-Martín, Patricia Rijo, Babatunji Emmanuel Oyinloye
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-21 (2024)
Abstract Prostate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize computational methods to explore potential anti-PCa compounds based on differentially expressed gen
Externí odkaz:
https://doaj.org/article/f213c29bbcba4fd79898f4ca5ad2d97e
Autor:
Ekowati Retnaningtyas, Andri Setiawan, Budi Susatia, Tanto Hariyanto, Ni Luh Putu Eka Sudiwati
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 12, Iss 4, Pp 735-747 (2024)
Context: The search for a safe and effective anti-diabetic medication has escalated due to the unfavorable side effects of synthetic drugs and the geometric rise in diabetes mellitus cases. Ruellia tuberosa is an important medicinal plant that can po
Externí odkaz:
https://doaj.org/article/0ad131c93c0141329580734ab7cdbdac