Zobrazeno 1 - 10 of 24 473 pro vyhledávání: '"adhesive interactions"'
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Subverting Attachment to Prevent Attacking : Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion Cell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions with the extracellular matrix, and the establishment of effector programs. Proper immune control of cancer strongly depends on all these events occurring in a highly accurate spatiotemporal sequence. In response to cancer-associated inflammatory signals, effector immune cells navigating the bloodstream shift from their patrolling exploratory migration mode to establish adhesive interactions with vascular endothelial cells. This interaction enables them to extravasate through the blood vessel walls and access the cancer site. Further adhesive interactions within the tumor microenvironment (TME) are crucial for coordinating their distribution in situ and for mounting an effective anti-tumor immune response. In this review, we examine how alterations of adhesion cues in the tumor context favor tumor escape by affecting effector immune cell infiltration and trafficking within the TME. We discuss the mechanisms by which tumors directly modulate immune cell adhesion and migration patterns to affect anti-tumor immunity and favor tumor evasion. We also explore indirect immune escape mechanisms that involve modifications of TME characteristics, such as vascularization, immunogenicity, and structural topography. Finally, we highlight the significance of these aspects in designing more effective drug treatments and cellular immunotherapies.
Autor: Mastrogiovanni, Marta1,2 (AUTHOR) marta.mastrogiovanni@einsteinmed.edu, Donnadieu, Emmanuel3 (AUTHOR) emmanuel.donnadieu@inserm.fr, Pathak, Rajiv4 (AUTHOR) rajivpathak17@gmail.com, Di Bartolo, Vincenzo5 (AUTHOR) vincenzo.di-bartolo@pasteur.fr
Publikováno v: Biology (2079-7737). Nov2024, Vol. 13 Issue 11, p860. 41p.
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6
Akademický článek
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
Autor: Michela Terri, Pilar Sandoval, Giulio Bontempi, Claudia Montaldo, Henar Tomero-Sanz, Valeria de Turris, Flavia Trionfetti, Lucía Pascual-Antón, Irene Clares-Pedrero, Cecilia Battistelli, Sergio Valente, Clemens Zwergel, Antonello Mai, Laura Rosanò, Miguel Ángel del Pozo, Miguel Sánchez-Álvarez, Carlos Cabañas, Marco Tripodi, Manuel López-Cabrera, Raffaele Strippoli
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-24 (2024)
Abstract Background Peritoneal metastasis, which accounts for 85% of all epithelial ovarian carcinoma (EOC) metastases, is a multistep process that requires the establishment of adhesive interactions between cancer cells and the peritoneal membrane.
Externí odkaz: https://doaj.org/article/c0bff25f461d43e3bfdafed5446dc3a7
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7
Report
On the long and short-range adhesive interactions in viscoelastic contacts
Autor: Violano, Guido, Afferrante, Luciano
Recently, tribologists have shown increasing interest in rate-dependent phenomena occurring in viscoelastic fractures. However, in some cases, conflicting results are obtained despite the use of similar theoretical models. For this reason, we try to
Externí odkaz: http://arxiv.org/abs/2202.02267
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8
Akademický článek
Adhesive interactions within microbial consortia can be differentiated at the single-cell level through expansion microscopy.
Autor: Pu-Ting Dong1 pdong@forsyth.org, Wenyuan Shi1, Xuesong He1, Borisy, Gary G.1 gborisy@forsyth.org
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 11/26/2024, Vol. 121 Issue 48, p1-11. 18p.
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CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling.
Autor: Bowman RL; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Kim J; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Eom DS; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA.; Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.; UC Irvine Skin Biology Resource Center, University of California, Irvine, CA 92697, USA.
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 28. Date of Electronic Publication: 2024 Sep 28.
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