Zobrazeno 1 - 10
of 362
pro vyhledávání: '"adhesion GPCR"'
Autor:
Jone Marita Kvam, Maja Lind Nybo, Lola Torz, Riia Karolina Sustarsic, Kristian Høj Reveles Jensen, John Erik Nielsen, Hanne Frederiksen, Sarina Gadgaard, Katja Spiess, Steen Seier Poulsen, Jesper Skovhus Thomsen, Pamela Cowin, Martin Blomberg Jensen, Takeshi Kurita, Mette Marie Rosenkilde
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of most of these malform
Externí odkaz:
https://doaj.org/article/cbc282de4565446c8b17c22dbf377664
Autor:
Sandra Žáčková, Marcela Pávová, Jana Trylčová, Jitka Chalupová, Anastasiia Priss, Ondřej Lukšan, Jan Weber
Publikováno v:
Cells, Vol 13, Iss 10, p 791 (2024)
Adhesion G protein-coupled receptors (aGPCRs) play an important role in neurodevelopment, immune defence and cancer; however, their role throughout viral infections is mostly unexplored. We have been searching for specific aGPCRs involved in SARS-CoV
Externí odkaz:
https://doaj.org/article/e28df66bff804be5adc544f42663c831
Autor:
Peter Kösters, Salvador Cazorla-Vázquez, René Krüger, Christoph Daniel, Eva Vonbrunn, Kerstin Amann, Felix B. Engel
Publikováno v:
Cells, Vol 13, Iss 10, p 874 (2024)
Uncovering the function of understudied G protein-coupled receptors (GPCRs) provides a wealth of untapped therapeutic potential. The poorly understood adhesion GPCR Gpr126 (Adgrg6) is widely expressed in developing kidneys. In adulthood, Gpr126 expre
Externí odkaz:
https://doaj.org/article/b196a51cdb454aaa876743a4fc8f9da2
Autor:
Gunnar Kleinau, Amal Hassan Ali, Franziska Wiechert, Michal Szczepek, Andrea Schmidt, Christian M.T. Spahn, Ines Liebscher, Torsten Schöneberg, Patrick Scheerer
Publikováno v:
Pharmacological Research, Vol 197, Iss , Pp 106971- (2023)
The class B2 of GPCRs known as adhesion G protein-coupled receptors (aGPCRs) has come under increasing academic and nonacademic research focus over the past decade due to their physiological importance as mechano-sensors in cell-cell and cell-matrix
Externí odkaz:
https://doaj.org/article/4bd3ee6180ce4632b09ce48a660071c3
Akademický článek
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Autor:
Abhishek Kumar Singh, Hsi-Hsien Lin
Publikováno v:
Biomedical Journal, Vol 44, Iss 5, Pp 534-547 (2021)
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation
Externí odkaz:
https://doaj.org/article/6c393340044d4d2885bc824001406153
Autor:
James P Bridges, Caterina Safina, Bernard Pirard, Kari Brown, Alyssa Filuta, Ravichandran Panchanathan, Rochdi Bouhelal, Nicole Reymann, Sejal Patel, Klaus Seuwen, William E Miller, Marie-Gabrielle Ludwig
Publikováno v:
eLife, Vol 11 (2022)
The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the physiological importance of autocatalytic cleavage upstream of the agonistic pep
Externí odkaz:
https://doaj.org/article/db418f7022854a65a93d19d7b20cf8f1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Salvador Cazorla-Vázquez, Peter Kösters, Simone Bertz, Frederick Pfister, Christoph Daniel, Mark Dedden, Sebastian Zundler, Tilman Jobst-Schwan, Kerstin Amann, Felix B. Engel
Publikováno v:
Cells, Vol 12, Iss 15, p 1988 (2023)
Adhesion G protein-coupled receptors (aGPCRs) comprise the second-largest class of GPCRs, the most common target for approved pharmacological therapies. aGPCRs play an important role in development and disease and have recently been associated with t
Externí odkaz:
https://doaj.org/article/fa43d8788f544b4487d78515f8317ff8
Autor:
Caroline Wilde, Paulomi Mehta Chaudhry, Rong Luo, Kay-Uwe Simon, Xianhua Piao, Ines Liebscher
Publikováno v:
Cells, Vol 12, Iss 11, p 1551 (2023)
GPR126/ADGRG6, a member of the adhesion G-protein-coupled receptor family, balances cell differentiation and proliferation through fine-tuning of intracellular cAMP levels, which is achieved through coupling to Gs and Gi proteins. While GPR126-mediat
Externí odkaz:
https://doaj.org/article/65cdef54df4a4dc590c0e1febd30ddf4