Zobrazeno 1 - 10
of 312
pro vyhledávání: '"adenylation domain"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 321-330 (2024)
Several under-explored Aspergillus sp. produce intriguing heptapeptides containing a γ-aminobutyric acid (GABA) residue with as yet unknown biological functions. In this study, a new GABA-containing heptapeptide – unguisin J (1) – along with kno
Externí odkaz:
https://doaj.org/article/46568e21c00244a1b7a147d43b796093
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 445-451 (2024)
The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins. Hence, the inhibition of A-domains could
Externí odkaz:
https://doaj.org/article/fda6b33ee917401da302b4b9d9863f7f
Publikováno v:
Marine Drugs, Vol 22, Iss 8, p 349 (2024)
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The
Externí odkaz:
https://doaj.org/article/0e500052f53c48028e4fa263110e0ec2
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Brevilaterin A-E, a novel class of multi-component cationic antimicrobial lipopeptides, were biosynthesized by a non-ribosomal peptides synthetase (NRPS) in Brevibacillus laterosporus. However, the antimicrobial abilities of diffe
Externí odkaz:
https://doaj.org/article/0c738c459778484d8922189b86b6c282
Akademický článek
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Publikováno v:
Antibiotics, Vol 12, Iss 4, p 787 (2023)
Dithiolopyrrolone antibiotics are well known for their outstanding biological activities, and their biosynthesis has been studied vigorously. However, the biosynthesis mechanism of the characteristic bicyclic scaffold is still unknown after years of
Externí odkaz:
https://doaj.org/article/6b1e1ad965fa4c9bba187a2d33b7c0d9
Akademický článek
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Autor:
Kemin Tan, Min Zhou, Robert P. Jedrzejczak, Ruiying Wu, Raul A. Higuera, Dominika Borek, Gyorgy Babnigg, Andrzej Joachimiak
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 14-24 (2020)
The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be les
Externí odkaz:
https://doaj.org/article/fa10c6e1bbae4aabb592b0fa413c8b9d
Autor:
Swati Sinha, Choy-Eng Nge, Chung Yan Leong, Veronica Ng, Sharon Crasta, Mohammad Alfatah, Falicia Goh, Kia-Ngee Low, Huibin Zhang, Prakash Arumugam, Alexander Lezhava, Swaine L. Chen, Yoganathan Kanagasundaram, Siew Bee Ng, Frank Eisenhaber, Birgit Eisenhaber
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-18 (2019)
Abstract Background Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but failed to find any putative biosynthetic gene cluster that could account
Externí odkaz:
https://doaj.org/article/7802baec2e984d30bb9af5de5f8a5b7c
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Ohmyungsamycins (OMSs) A and B are cyclic depsipeptides produced by marine Streptomyces strains, which are synthesized by a non-ribosomal peptide synthetase. Notably, OMS A exhibits more potent activity against Mycobacterium tuberculosis and human ca
Externí odkaz:
https://doaj.org/article/c0d7f875e1364e19961da6c18b8861d1