Zobrazeno 1 - 10
of 3 208
pro vyhledávání: '"adenosine A2A receptor"'
Autor:
Riyan Alifbi Putera Irsal, Gusnia Meilin Gholam, Dzikri Anfasa Firdaus, Novian Liwanda, Fernanda Chairunisa
Publikováno v:
Borneo Journal of Pharmacy, Vol 7, Iss 2 (2024)
Parkinson's disease is a global health challenge affecting over 10 million individuals worldwide, leading to increased disability-adjusted life years (DALYs) and a rise in mortality rates. This study explores the potential anti-Parkinson's properties
Externí odkaz:
https://doaj.org/article/3ad72a8cba424571b768ba52ececa4c6
Autor:
Houyang Chen, Genbao Xing, Wenqing Xu, Ying Chen, Leizhen Xia, Hua Huang, Jialv Huang, Qing Hong, Tao Luo, Hao Wang, Qiongfang Wu
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundThe involvement of ATP and cAMP in sperm function has been extensively documented, but the understanding of the role of adenosine and adenosine receptors remains incomplete. This study aimed to examine the presence of adenosine A2A receptor
Externí odkaz:
https://doaj.org/article/971dfe4886a44ffa8691bbd16bd32140
Autor:
Anna Wójcik, Aleksander Górny, Justyna Chwiejczak, Julita Młynarska, Jan Kościan, Karolina Szczerkowska, Anna Seroka, Maria Mitkowska, Maria Rybicka, Michał Obrębski
Publikováno v:
Journal of Education, Health and Sport, Vol 71 (2024)
Introduction and purpose: Parkinson’s disease (PD) is the second most common neurodegenerative disease, mainly characterized by motor impairment with symptoms including rigidity, bradykinesia, rest tremor and imbalance. It develops upon degeneratio
Externí odkaz:
https://doaj.org/article/b6e2e715f4f6406eb762ab66a3453190
Autor:
Taku Hatano, Renpei Sengoku, Hiroshi Nagayama, Naotake Yanagisawa, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Kenichi Kaida, Ryoko Ihara, Kazutomi Kanemaru, Osamu Kano
Publikováno v:
Neurology and Therapy, Vol 13, Iss 2, Pp 323-338 (2024)
Abstract Introduction A higher levodopa dose is a risk factor for motor complications in Parkinson’s disease (PD). Istradefylline (IST) is used as adjunctive treatment to levodopa in PD patients with off episodes, but its impact on levodopa dose ti
Externí odkaz:
https://doaj.org/article/297912391b29425383cd3fe2f9e7b7d9
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Joint capsule fibrosis, a common complication of joint immobilization, is mainly characterized by abnormal collagen deposition. The present study aimed to investigate the effect of extracorporeal shock wave therapy (ESWT) on reduced collagen
Externí odkaz:
https://doaj.org/article/b7894925934041648ce70c463fbb43fc
Autor:
Yeon-Soo Kim, Bo Kyung Lee, Cha Soon Kim, Young-Seob Lee, Yoon Ji Lee, Kwan-Woo Kim, Dae Young Lee, Yi-Sook Jung
Publikováno v:
Nutrients, Vol 16, Iss 16, p 2611 (2024)
Insomnia is a common sleep disorder with significant societal and economic impacts. Current pharmacotherapies for insomnia are often accompanied by side effects, necessitating the development of new therapeutic drugs. In this study, the hypnotic effe
Externí odkaz:
https://doaj.org/article/49ac3568a3fc41f3939dc04695f7a2e4
Autor:
Jorge Lindo, Célia Nogueira, Rui Soares, Nuno Cunha, Maria Rosário Almeida, Lisa Rodrigues, Patrícia Coelho, Francisco Rodrigues, Rodrigo A. Cunha, Teresa Gonçalves
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6135 (2024)
SARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammator
Externí odkaz:
https://doaj.org/article/bfcff13351ab4833b9003b258e08bcc7
Autor:
Yutaro Ohno, Eri Okita, Mika Kawai-Uchida, Youji Shoukei, Kazuhiro Soshiroda, Tomoyuki Kanda, Shinichi Uchida
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 3, Pp 193-199 (2023)
The adenosine A2A receptor antagonist/inverse agonist, KW-6356 has been shown to be effective in Parkinson's disease (PD) patients as monotherapy and as an adjunct therapy to L-3,4-dihydroxyphenylalanine (L-DOPA)/decarboxylase inhibitor. However, the
Externí odkaz:
https://doaj.org/article/c813e07e2733429a92c3bfbdfcba0ff4
Autor:
Chia-Chang Huang, Hsiao-Chin Shen, Roger Lin, Ying-Ying Yang, Yun-Chien Chang, Tsai-Ling Liao, Shiang-Fen Huang, Han-Chieh Lin, Ming-Chih Hou
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 1, Pp 50-60 (2023)
Cirrhosis-related hepatic and renal endothelial dysfunction is characterized by macrophage-endothelium adhesion-mediated inflammation, glycocalyx/barrier damage, and impaired vasodilation. Activation of adenosine A2A receptor (A2AR) protects cirrhoti
Externí odkaz:
https://doaj.org/article/a83ffc879d70466e95d6fadfa3173ebd
Publikováno v:
Folia Neuropathologica, Vol 61, Iss 2, Pp 217-223 (2023)
Parkinson’s disease occurs due to loss of dopaminergic neurons, which alters the behavioural changes. The present study evaluates the effect of exercise on neurodegeneration against Parkinson’s disease (PD) rat model and postulates its effect on
Externí odkaz:
https://doaj.org/article/2d169db39fd14cad9cfa210ec90c768b