Zobrazeno 1 - 10
of 138
pro vyhledávání: '"adavosertib"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2449-2460 (2024)
Wenhao Zhang,1,2 Qingli Li,1,2,* Rutie Yin1,2,* 1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Birth Defects and Related Diseases
Externí odkaz:
https://doaj.org/article/741132a1f49e44bba9ae2379307fa5e6
Autor:
Yamamoto, Gaku a, b, c, d, 1, Tanaka, Kosuke b, e, f, 1, ⁎⁎, Kamata, Ryo a, b, Saito, Hitoshi a, b, Yamamori-Morita, Tomoko a, b, Nakao, Takehiro a, b, Liu, Jie b, Mori, Shunta b, Yagishita, Shigehiro g, Hamada, Akinobu g, Shinno, Yuki h, Yoshida, Tatsuya h, Horinouchi, Hidehito h, Ohe, Yuichiro h, Watanabe, Shun-Ichi i, Yatabe, Yasushi j, Kitai, Hidenori d, Konno, Satoshi d, Kobayashi, Susumu S. b, k, Ohashi, Akihiro a, b, ⁎
Publikováno v:
In Cancer Letters 28 February 2025 611
Autor:
Shunsuke Kondo, Yuki Katsuya, Kan Yonemori, Keiko Komuro, Masatoshi Sugeno, Toshio Kawata, Dana Ghiorghiu, Didier Meulendijks, Noboru Yamamoto
Publikováno v:
Cancer Treatment and Research Communications, Vol 39, Iss , Pp 100809- (2024)
Introduction: We aimed to assess the safety, pharmacokinetic profile, and antitumor activity of adavosertib monotherapy in Japanese patients with advanced solid tumors. Materials and methods: This was a single-center, open-label, phase I study with t
Externí odkaz:
https://doaj.org/article/c5e3b71ea3544fcba7e6ccf11b726a69
Autor:
Meryem H. Cetin, Thorsten Rieckmann, Konstantin Hoffer, Britta Riepen, Sabrina Christiansen, Fruzsina Gatzemeier, Simon Feyerabend, Melanie Schoof, Ulrich Schüller, Cordula Petersen, Martin Mynarek, Kai Rothkamm, Malte Kriegs, Nina Struve
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract Background The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2–7 (EGFRvIII) being amongst the most common genomic mutations. EGFRvIII is heter
Externí odkaz:
https://doaj.org/article/465e6b79a1ff4eba9893278ef9efb89a
Akademický článek
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Akademický článek
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Autor:
Louise C Brown, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Susan D Richman, Philip Quirke, Rachel Butler, Helen Roberts, Janet Graham, Richard H Wilson, Timothy S Maughan
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 9, Iss 9 (2022)
Background: Complex trials with innovative designs are becoming increasingly common and offer the potential to improve patient outcomes in a shorter time frame. There is evidence that patients with colorectal cancer fall into different subgroups with
Externí odkaz:
https://doaj.org/article/a710ce8c7ebb4534b2145ccccfea160e
Autor:
Pia Roering, Arafat Siddiqui, Vanina D. Heuser, Swapnil Potdar, Piia Mikkonen, Jaana Oikkonen, Yilin Li, Sanna Pikkusaari, Krister Wennerberg, Johanna Hynninen, Seija Grenman, Kaisa Huhtinen, Annika Auranen, Olli Carpén, Katja Kaipio
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveA major challenge in the treatment of platinum-resistant high-grade serous ovarian cancer (HGSOC) is lack of effective therapies. Much of ongoing research on drug candidates relies on HGSOC cell lines that are poorly documented. The goal of
Externí odkaz:
https://doaj.org/article/682cdd5529f243d1abfe1e21b24f7510
Autor:
Voutsadakis IA
Publikováno v:
Cancer Management and Research, Vol Volume 12, Pp 10423-10437 (2020)
Ioannis A Voutsadakis1,2 1Algoma District Cancer Program, Sault Area Hospital, Sault Ste. Marie, Ontario, Canada; 2Section of Internal Medicine, Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, CanadaCorrespondenc
Externí odkaz:
https://doaj.org/article/31eda6485d38484fb6b71b36b88c8d84
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
p53 is among the most frequently mutated tumor suppressor genes given its prevalence in >50% of all human cancers. One critical tumor suppression function of p53 is to regulate transcription of downstream genes and maintain genomic stability by induc
Externí odkaz:
https://doaj.org/article/2fdc5e68a28a40c989d0275fa29738d2