Výsledky vyhledávání - "adaptive mutations"

Akademický článek

Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines

Autor: Colin A. Russell, Ron A. M. Fouchier, Parinaz Ghaswalla, Yoonyoung Park, Nevena Vicic, Jintanat Ananworanich, Raffael Nachbagauer, Deborah Rudin

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)

ABSTRACTInfluenza remains a public health threat, partly due to suboptimal effectiveness of vaccines. One factor impacting vaccine effectiveness is strain mismatch, occurring when vaccines no longer match circulating strains due to antigenic drift or

Externí odkaz: https://doaj.org/article/6a73d975b6bf4fc69c8881c1d8d5e4bf

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Akademický článek

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

Autor: Asami Osugi, Aki Tamaru, Takashi Yoshiyama, Tomotada Iwamoto, Satoshi Mitarai, Yoshiro Murase

Publikováno v: Microbiology Spectrum, Vol 12, Iss 7 (2024)

ABSTRACT Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decade

Externí odkaz: https://doaj.org/article/862d37d0f4e945cb942d585fdd884ab5

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Akademický článek

Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters

Autor: Foteini Karapanagioti, Úlfur Águst Atlason, Dirk J Slotboom, Bert Poolman, Sebastian Obermaier

Publikováno v: eLife, Vol 13 (2024)

The emergence of new protein functions is crucial for the evolution of organisms. This process has been extensively researched for soluble enzymes, but it is largely unexplored for membrane transporters, even though the ability to acquire new nutrien

Externí odkaz: https://doaj.org/article/93f26e7cfbb0489e98c6f142a1f80aae

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Akademický článek

The adaptive potential of North American subtype H7N2 avian influenza viruses to mammals

Autor: Aleksandr V. Lyashko, Irina A. Rudneva, Dmitrii N. Shcherbinin, Natalia F. Lomakina, Anastasia A. Treshchalina, Irina M. Kupriyanova, Alexandra S. Gambaryan, Elena B. Timofeeva, Aleksandr A. Shilov, Galina K. Sadykova, Alexey G. Prilipov, Boris I. Timofeev, Maxim M. Shmarov, Elena L. Ryazanova, Tatiana A. Timofeeva

Publikováno v: Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 100, Iss 6, Pp 442-453 (2024)

Introduction. H7 subtype avian influenza viruses causing severe epizootics among birds are phylogenetically different in the Eastern and Western hemispheres. Numerous human infections caused by these viruses in the Eastern hemisphere indicate that H7

Externí odkaz: https://doaj.org/article/fbe7198596a94097b60e0e61ed44a680

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Akademický článek

The end of the reign of a 'master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates

Autor: Mylène C. Trottier, Thays de Oliveira Pereira, Marie-Christine Groleau, Lucas R. Hoffman, Ajai A. Dandekar, Eric Déziel

Publikováno v: mBio, Vol 15, Iss 3 (2024)

ABSTRACT Pseudomonas aeruginosa, a bacterium causing infections in immunocompromised individuals, regulates several of its virulence functions using three interlinked quorum sensing (QS) systems (las, rhl, and pqs). Despite its presumed importance in

Externí odkaz: https://doaj.org/article/6edfb6c216cc4837b0609d1cfccc41f6

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Akademický článek

Molecular Markers and Mechanisms of Influenza A Virus Cross-Species Transmission and New Host Adaptation

Autor: Xinyi Guo, Yang Zhou, Huijun Yan, Qing An, Chudan Liang, Linna Liu, Jun Qian

Publikováno v: Viruses, Vol 16, Iss 6, p 883 (2024)

Influenza A viruses continue to be a serious health risk to people and result in a large-scale socio-economic loss. Avian influenza viruses typically do not replicate efficiently in mammals, but through the accumulation of mutations or genetic reasso

Externí odkaz: https://doaj.org/article/5d5c9249070848dbac9021157c2ffd5d

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Akademický článek

Autor: Kazuhisa Okada, Amonrattana Roobthaisong, Shigeyuki Hamada

Publikováno v: mSystems, Vol 8, Iss 5 (2023)

ABSTRACT Understanding the survival strategies of pandemic cholera pathogens in aquatic environments is important for preventing their dissemination. Here, we report a phenomenon wherein long-term cultivation of Vibrio cholerae under nutrient-limited

Externí odkaz: https://doaj.org/article/ddc7caa43ee649a4846e714ed284842e

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