Zobrazeno 1 - 10
of 71
pro vyhledávání: '"acvr1b"'
Akademický článek
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Autor:
Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Thompson, Aris N Economides, Vincent Idone
Publikováno v:
eLife, Vol 9 (2020)
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unex
Externí odkaz:
https://doaj.org/article/f046d1441e0d4e23a1f1b1baf6223516
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 821 (2021)
Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer. Genetic mutations in the activin signaling pathw
Externí odkaz:
https://doaj.org/article/16247d73699f4be69da7bfd907b914f9
Autor:
Michèle M. G. Hillege, Ricardo A. Galli Caro, Carla Offringa, Gerard M. J. de Wit, Richard T. Jaspers, Willem M. H. Hoogaars
Publikováno v:
Cells, Vol 9, Iss 2, p 375 (2020)
Transforming Growth Factor β (TGF-β) is involved in fibrosis as well as the regulation of muscle mass, and contributes to the progressive pathology of muscle wasting disorders. However, little is known regarding the time-dependent signalling of TGF
Externí odkaz:
https://doaj.org/article/1ced9a20c5474ed5ad75b0efd4925e6a
Akademický článek
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Autor:
Xin Hu, Yishen Xing, Ling Ren, Yahui Wang, Qian Li, Xing Fu, Qiyuan Yang, Lingyang Xu, Luc Willems, Junya Li, Lupei Zhang
Publikováno v:
Animals, Vol 9, Iss 11, p 859 (2019)
MicroRNAs modulate a variety of cellular events, including skeletal muscle development, but the molecular basis of their functions in fetal bovine skeletal muscle development is poorly understood. In this study, we report that bta-miR-24-3p promotes
Externí odkaz:
https://doaj.org/article/30697eb65e524f82afecf555c9362493
Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution
Autor:
Adel Boueiz, Betty Pham, Robert Chase, Andrew Lamb, Sool Lee, Zun Zar Chi Naing, Michael H. Cho, Margaret M. Parker, Phuwanat Sakornsakolpat, Craig P. Hersh, James D. Crapo, Andrew B. Stergachis, Ruth Tal-Singer, Dawn L. DeMeo, Edwin K. Silverman, Xiaobo Zhou, Peter J. Castaldi, Barry J. Make, Elizabeth A. Regan, Terri Beaty, Ferdouse Begum, Michael Cho, Marilyn G. Foreman, Eitan Halper-Stromberg, Lystra P. Hayden, Jacqueline Hetmanski, Brian D. Hobbs, John E. Hokanson, Nan Laird, Christoph Lange, Sharon M. Lutz, Merry-Lynn McDonald, Dandi Qiao, Emily S. Wan, Sungho Won, Dmitry Prokopenko, Mustafa Al Qaisi, Harvey O. Coxson, Teresa Gray, MeiLan K. Han, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, John D. Newell, James C. Ross, Raul San Jose Estepar, Joyce Schroeder, Jered Sieren, Douglas Stinson, Berend C. Stoel, Juerg Tschirren, Edwin Van Beek, Bram van Ginneken, Eva van Rikxoort, George Washko, Carla G. Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Camille Moore, Matt Strand, John Hughes, Gregory Kinney, Katherine Pratte, Kendra A. Young, Surya Bhatt, Jessica Bon, Barry Make, Carlos Martinez, Susan Murray, Elizabeth Regan, Xavier Soler, Russell P. Bowler, Katerina Kechris, Farnoush Banaei-Kashani, Y. Ivanov, K. Kostov, J. Bourbeau, M. Fitzgerald, P. Hernandez, K. Killian, R. Levy, F. Maltais, D. O’Donnell, J. Krepelka, J. Vestbo, E. Wouters, D. Quinn, P. Bakke, M. Kosnik, A. Agusti, J. Sauleda, Y. Feschenko, V. Gavrisyuk, L. Yashina, N. Monogarova, P. Calverley, D. Lomas, W. MacNee, D. Singh, J. Wedzicha, A. Anzueto, S. Braman, R. Casaburi, B. Celli, G. Giessel, M. Gotfried, G. Greenwald, Rancho Mirage, N. Hanania, D. Mahler, B. Make, S. Rennard, C. Rochester, P. Scanlon, D. Schuller, F. Sciurba, A. Sharafkhaneh, T. Siler, E. Silverman, A. Wanner, R. Wise, R. ZuWallack, H. Coxson, C. Crim, L. Edwards, R. Tal-Singer, J. Yates, B. Miller, Per Bakke, Amund Gulsvik
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 60(4), 388-398. American Thoracic Society
American Journal of Respiratory Cell and Molecular Biology, 60(4), 388-398. American Thoracic Society
Genome-wide association studies (GWAS) have identified multiple associations with emphysema apicobasal distribution (EABD), but the biological functions of these variants are unknown. To characterize the functions of EABD-associated variants, we inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac792debcc53f06a73a07f6861730e4
https://doi.org/10.1165/rcmb.2018-0110oc
https://doi.org/10.1165/rcmb.2018-0110oc
Publikováno v:
Genes & Cancer
Recently, we observed that the TGF-β pathway is altered in 39% of HCCs. The alterations are correlated with a raised HMGA2 level. Therefore, we compared genetic alterations of HMGA2 and 43 TGF-β pathway core genes in HCC patients from TCGA database
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f9492ad40bb47f4baddeaf5ca59b34
http://europepmc.org/articles/PMC7289907
http://europepmc.org/articles/PMC7289907
Akademický článek
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Autor:
Zhongjun Zhou, Xuewei Wu, Liliana Osório, Carlos Neideck, Guojun Sheng, Linsheng Wang, Zhixin Jiang
Publikováno v:
The Journal of Cell Biology
Proper regulation of NODAL signaling is fundamental for embryonic development and cancer. Osório et al. identify ISM1 as an extracellular antagonist of NODAL and uncover a novel molecular mechanism that negatively regulates NODAL signaling to contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf15c2e2bcb812dd62094a35383e89f
https://doi.org/10.1083/jcb.201801081
https://doi.org/10.1083/jcb.201801081