Cytotoxic T lymphocytes promote cytarabine-induced acute myeloid leukemia cell apoptosis via inhibiting Bcl-2 expression

Autor: Yan Zeng, Yi Su, Yan‑Rong Shuai, Yi Wang, Hai Yi, Li Fu, Rui Deng, Fang‑Yi Fan, Xiao‑Juan Miao, Guang‑Cui He

Publikováno v: Experimental and Therapeutic Medicine

Acute myeloid leukemia (AML) remains difficult to cure due to its drug tolerance and refractoriness. Immunotherapy is a growing area of cancer research, which has been applied for the treatment of numerous types of cancer, including leukemia. The pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c4a07f1c8e3ab1c9b2c948f14783de
https://doi.org/10.3892/etm.2017.4620

Defining the in vivo characteristics of acute myeloid leukemia cells behavior by intravital imaging

Autor: Delfim, Duarte, Saoirse, Amarteifio, Heather, Ang, Isabella Y, Kong, Nicola, Ruivo, Gunnar, Pruessner, Edwin D, Hawkins, Cristina, Lo Celso

Publikováno v: Immunology and Cell Biology

The majority of acute myeloid leukemia (AML) patients have a poor response to conventional chemotherapy. The survival of chemoresistant cells is thought to depend on leukemia‐bone marrow (BM) microenvironment interactions, which are not well unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95cdf8c5ea866af11cd219f920984ba6
https://pubmed.ncbi.nlm.nih.gov/30422351

Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities

Autor: María del Carmen Boyano-Adánez, Javier Ramos, Elena de Blas, Patricio Aller, María Cristina Estañ, María del Carmen Gómez de Frutos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancer Cell International
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

16 p.-8 fig.
Background: The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and MEK/ERK d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c259ce22719ddb70b25eb92e7d65d9
http://hdl.handle.net/10261/137143

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Inhibition of DNA Methyltransferase Activates Tumor Necrosis Factor α–Induced Monocytic Differentiation in Acute Myeloid Leukemia Cells

Autor: Luca A. Petruccelli, Anna Laurenzana, Francesco Paoletti, Maria E. Figueroa, Albert S. Baldwin, Ari Melnick, Filippa Pettersson, Wilson H. Miller

Publikováno v: Cancer Research. 69:55-64

Transcriptional silencing via promoter methylation of genes important for cell growth and differentiation plays a key role in myeloid leukemogenesis. We find that clinically achievable levels of 5-aza-2′-deoxycytidine (5-AZA-dC), a potent inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd77e125f1ffc8b97206e8a12d164ff
https://doi.org/10.1158/0008-5472.can-08-0245