Zobrazeno 1 - 10
of 4 465
pro vyhledávání: '"activity dependent"'
Autor:
Claudio Peter D’Incal, Elisa Cappuyns, Kaoutar Choukri, Kevin De Man, Kristy Szrama, Anthony Konings, Lina Bastini, Kim Van Meel, Amber Buys, Michele Gabriele, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Fabio Mohn, Marc Bühler, Nathalie Van der Aa, Anke Van Dijck, R. Frank Kooy, Wim Vanden Berghe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Heterozygous de novo mutations in the Activity-Dependent Neuroprotective Homeobox (ADNP) gene underlie Helsmoortel-Van der Aa syndrome (HVDAS). Most of these mutations are situated in the last exon and we previously demonstrated escape from
Externí odkaz:
https://doaj.org/article/f7c381ec5b634584bcd2d05f0e32ea1f
Autor:
Kaijie Ma, Daoqi Zhang, Kylee McDaniel, Maria Webb, Samuel S. Newton, Francis S. Lee, Luye Qin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic heterogeneity and more prevalent in males than females. We and others hypothesize that diminished activity-dependent neural signaling is a common molecular
Externí odkaz:
https://doaj.org/article/31996908403a4fb8b57495b73c345ae4
Autor:
Claudio D’Incal, Anke Van Dijck, Joe Ibrahim, Kevin De Man, Lina Bastini, Anthony Konings, Ellen Elinck, Claudia Theys, Illana Gozes, Zlatko Marusic, Mirna Anicic, Jurica Vukovic, Nathalie Van der Aa, Ligia Mateiu, Wim Vanden Berghe, R. Frank Kooy
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-32 (2024)
Abstract Background Helsmoortel–Van der Aa syndrome is a neurodevelopmental disorder in which patients present with autism, intellectual disability, and frequent extra-neurological features such as feeding and gastrointestinal problems, visual impa
Externí odkaz:
https://doaj.org/article/0d40e2e4341b4789a86693c044db578c
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
To understand how neurons and neural circuits function during behaviors, it is essential to record neuronal activity in the brain in vivo. Among the various technologies developed for recording neuronal activity, molecular tools that induce gene expr
Externí odkaz:
https://doaj.org/article/b44594e72e8a40f9b258aac5542ae0ce
Autor:
Akio Tsuboi
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Various mammals have shown that sensory stimulation plays a crucial role in regulating the development of diverse structures, such as the olfactory bulb (OB), cerebral cortex, hippocampus, and retina. In the OB, the dendritic development of excitator
Externí odkaz:
https://doaj.org/article/9353c49e921245f4975f73a3da3227b7
Autor:
Naoki Nakagawa, Takuji Iwasato
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
For neural circuit construction in the brain, coarse neuronal connections are assembled prenatally following genetic programs, being reorganized postnatally by activity-dependent mechanisms to implement area-specific computational functions. Activity
Externí odkaz:
https://doaj.org/article/d1b01417c5634475951bc5685c2231ec
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Despite considerable advancement of first choice treatment (pharmacological, physical therapy, etc.) over many decades, neurological disorders still represent a major portion of the worldwide disease burden. Particularly concerning, the trend is that
Externí odkaz:
https://doaj.org/article/32cd34a344244f13819960f4a261575e
Autor:
Bo Pang, Xiaoyan Wu, Hailun Chen, Yiwen Yan, Zibo Du, Zihan Yu, Xiai Yang, Wanshan Wang, Kangrong Lu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
The theory of engrams, proposed several years ago, is highly crucial to understanding the progress of memory. Although it significantly contributes to identifying new treatments for cognitive disorders, it is limited by a lack of technology. Several
Externí odkaz:
https://doaj.org/article/01fc3535cb7c4c479a13a0ea9882a187
Autor:
Claudio Peter D’Incal, Kirsten Esther Van Rossem, Kevin De Man, Anthony Konings, Anke Van Dijck, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Illana Gozes, Wim Vanden Berghe, R. Frank Kooy
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-28 (2023)
Abstract Background Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism cluster on a relatively limited number of cellular pathways, including chromatin remodeling.
Externí odkaz:
https://doaj.org/article/4fd1319c8f87495ca67f5845e1e6e030
Autor:
Daniela A Gutiérrez, América Chandía-Cristi, María José Yáñez, Silvana Zanlungo, Alejandra R Álvarez
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 2, Pp 237-243 (2023)
Our ability to learn and remember depends on the active formation, remodeling, and elimination of synapses. Thus, the development and growth of synapses as well as their weakening and elimination are essential for neuronal rewiring. The structural re
Externí odkaz:
https://doaj.org/article/cb1ccfc5b05c4fcaa39cba3ad18fca93