Zobrazeno 1 - 10
of 149
pro vyhledávání: '"action potential clamp"'
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106059- (2023)
SCN1A gain-of-function variants are associated with early onset developmental and epileptic encephalopathies (DEEs) that possess distinct clinical features compared to Dravet syndrome caused by SCN1A loss-of-function. However, it is unclear how SCN1A
Externí odkaz:
https://doaj.org/article/76010b18ccb040b599dbbf5fedb5379f
Autor:
Berecki, Géza, Howell, Katherine B., Deerasooriya, Yadeesha H., Cilio, Maria Roberta, Oliva, Megan K., Kaplan, David, Scheffer, Ingrid E., Berkovic, Samuel F., Petrou, Steven
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Jun 01. 115(24), E5516-E5525.
Externí odkaz:
https://www.jstor.org/stable/26510137
Akademický článek
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Autor:
Arie O. Verkerk, Ronald Wilders
Publikováno v:
International journal of molecular sciences, 24(8):7264. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7264
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7264
The pacemaker activity of the sinoatrial node (SAN) has been studied extensively in animal species but is virtually unexplored in humans. Here we assess the role of the slowly activating component of the delayed rectifier K+ current (IKs) in human SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7da4fd658da12ea93112f9976e6a8d2
http://www.scopus.com/inward/record.url?scp=85156232708&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85156232708&partnerID=8YFLogxK
Yes
We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsible
We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsible
Externí odkaz:
http://hdl.handle.net/10454/16481
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsible for nega
Externí odkaz:
https://doaj.org/article/b360a5c74cac4bcfadaff480a35b716b
Akademický článek
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Akademický článek
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Autor:
John R Clay
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2016)
Action potential clamp (AP-clamp) recordings of the delayed rectifier K+ current IK and the fast-activated Na+ current INa in rat hippocampal mossy fiber boutons (MFBs) are analyzed using a computational technique recently reported. The method is imp
Externí odkaz:
https://doaj.org/article/99f6323090ba44ff8e5a7b97422d262d
Autor:
Maria Camporesi, Teun P. de Boer, Chon Lok Lei, Stefano Severi, Gary R. Mirams, Chiara Bartolucci
Publikováno v:
CinC
As drugs can be multichannel blockers it is important to assess their cardiac safety taking into account multiple currents. In silico action potential (AP) models have been proposed for being able to integrate drugs effect on ionic currents and gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6875f7328b1d5576c321cb347359a84
http://hdl.handle.net/11585/821432
http://hdl.handle.net/11585/821432