Zobrazeno 1 - 10
of 573
pro vyhledávání: '"actinium-225"'
Autor:
A. K. M. Rezaur Rahman, Mahathe Hasan Babu, Mustofa Khalid Ovi, Md. Mahiuddin Zilani, Israt Sultana Eithu, Amit Chakraborty
Publikováno v:
Journal of Medical Physics, Vol 49, Iss 2, Pp 137-147 (2024)
The utilization of actinium-225 (225Ac) radionuclides in targeted alpha therapy for cancer was initially outlined in 1993. Over the past two decades, substantial research has been conducted, encompassing the establishment of 225Ac production methods,
Externí odkaz:
https://doaj.org/article/fd3d3f7c0ce94a51827a26a032bbaa64
Autor:
Miguel Toro-González, Ngozi Akingbesote, Amber Bible, Debjani Pal, Brian Sanders, Alexander S. Ivanov, Santa Jansone-Popova, Ilja Popovs, Paul Benny, Rachel Perry, Sandra Davern
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Targeted alpha therapy (TAT) relies on chemical affinity or active targeting using radioimmunoconjugates as strategies to deliver α-emitting radionuclides to cancerous tissue. These strategies can be affected by transmetalation of the paren
Externí odkaz:
https://doaj.org/article/c718824527bd4c548764d816c9f11ed2
Autor:
Rajan Singh, Anand K. Thotakura, Suresh Alati, Alla Lisok, Zirui Jiang, Vanessa F. Merino, Il Minn, Santosh Yadav, Mark C. Markowski, Yasser Ged, Christian P. Pavlovich, Nirmish Singla, Lilja B. Solnes, Michael A. Gorin, Martin G. Pomper, Steven P. Rowe, Sangeeta Ray Banerjee
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionRenal cell carcinoma (RCC) represents cancer originating from the renal epithelium and accounts for > 90% of cancers in the kidney. Prostate-specific membrane antigen (PSMA) is overexpressed in tumor-associated neovascular endothelial cel
Externí odkaz:
https://doaj.org/article/0b43bcfa255e43f883bee194298d2a44
Autor:
Monika Tulik, Radosław Kuliński, Zbisław Tabor, Beata Brzozowska, Piotr Łaba, Frank Bruchertseifer, Alfred Morgenstern, Leszek Królicki, Jolanta Kunikowska
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-17 (2024)
Abstract Background A new, alternative option for patients with recurrent glioblastoma is targeted alpha therapy (TAT), in the form of a local administration of substance P (neurokinin type 1 receptor ligand, NK-1) labelled with 225Ac. The purpose of
Externí odkaz:
https://doaj.org/article/1666ee8f492e4d57b40dbaf1c935c18c
Autor:
Eline L. Hooijman, Valery Radchenko, Sui Wai Ling, Mark Konijnenberg, Tessa Brabander, Stijn L. W. Koolen, Erik de Blois
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-30 (2024)
Abstract Background In the past years, there has been a notable increase in interest regarding targeted alpha therapy using Ac-225, driven by the observed promising clinical anti-tumor effects. As the production and technology has advanced, the avail
Externí odkaz:
https://doaj.org/article/ea3b5e881d0946de8f0c7f54613517f6
Autor:
Sui wai Ling, Astrid A. M. van der Veldt, Mark Konijnenberg, Marcel Segbers, Eline Hooijman, Frank Bruchertseifer, Alfred Morgenstern, Erik de Blois, Tessa Brabander
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Life expectancy of patients with metastatic castration-resistant prostate cancer (mCRPC) is still limited despite several systemic treatments. Within five years after diagnosis of primary prostate cancer, 10–20% of the patients
Externí odkaz:
https://doaj.org/article/7895c2af2d0a42f0969b2758f379db83
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy which may benefit from radioimmunotherapy. Previously, [177Lu]Lu-DOTA-C595 has been developed as a beta-emitting radioimmunoconjugate to target cancer-specific mu
Externí odkaz:
https://doaj.org/article/d052f7feea314249b9b2145109491896
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Autor:
Anders Josefsson, Angel G. Cortez, Harikrishnan Rajkumar, Joseph D. Latoche, Ambika P. Jaswal, Kathryn E. Day, Mohammadreza Zarisfi, Lora H. Rigatti, Ziyu Huang, Jessie R. Nedrow
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-19 (2023)
Abstract Background The liver is a common site for metastatic disease for a variety of cancers, including colorectal cancer. Both primary and secondary liver tumors are supplied through the hepatic artery while the healthy liver is supplied by the po
Externí odkaz:
https://doaj.org/article/5bdb66bc79a74d4192cbef491bb17580
Publikováno v:
EJNMMI Physics, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract Background Radiopharmaceutical therapy (RPT) with alpha-emitting radionuclides has shown great promise in treating metastatic cancers. The successive emission of four alpha particles in the 225Ac decay chain leads to highly targeted and effe
Externí odkaz:
https://doaj.org/article/ffd9cccc23b5410eb16213e540fb3b2a