Quantitative regulation of the dynamic steady state of actin networks

Autor: Angelika Manhart, Téa Aleksandra Icheva, Christophe Guerin, Tobbias Klar, Rajaa Boujemaa-Paterski, Manuel Thery, Laurent Blanchoin, Alex Mogilner

Publikováno v: eLife, Vol 8 (2019)

Principles of regulation of actin network dimensions are fundamentally important for cell functions, yet remain unclear. Using both in vitro and in silico approaches, we studied the effect of key parameters, such as actin density, ADF/Cofilin concent

Externí odkaz: https://doaj.org/article/fab7c2ddcb384449b9c3f74d95f6b64d

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Autor: Kotila, Tommi, Wioland, Hugo, Enkavi, Giray, Kogan, Konstantin, Vattulainen, Ilpo, Jégou, Antoine, Romet-Lemonne, Guillaume, Lappalainen, Pekka

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-13213-2⟩

HFD-bound and HFD-free simulation systems presented in the paper; see table_of_simulations.pdf Contents of the simulation_archive: _FORCEFIELD: Force field parameters and topologies in GROMACS format amber-ff14SB.ff: The required force field paramete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321b7f24e8bf2bbdddee854b9115f9aa
http://link.springer.com/article/10.1038/s41467-019-13213-2

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Combinatorial genetic analysis of a network of actin disassembly-promoting factors

Autor: Casey A, Ydenberg, Adam, Johnston, Jaclyn, Weinstein, Danielle, Bellavance, Silvia, Jansen, Bruce L, Goode

Publikováno v: Cytoskeleton (Hoboken, N.j.)

The patterning of actin cytoskeleton structures in vivo is a product of spatially and temporally regulated polymer assembly balanced by polymer disassembly. While in recent years our understanding of actin assembly mechanisms has grown immensely, our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9da1e960fb50be4388f6a73dbc52108a
https://pubmed.ncbi.nlm.nih.gov/26147656

Coronin switches roles in actin disassembly depending on the nucleotide state of actin

Autor: Laurent Blanchoin, Meghal Gandhi, Vérane Achard, Bruce L. Goode

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2009, 34 (3), pp.364-74. ⟨10.1016/j.molcel.2009.02.029⟩
Molecular Cell, 2009, 34 (3), pp.364-74. ⟨10.1016/j.molcel.2009.02.029⟩

International audience; Rapid and polarized turnover of actin networks is essential for motility, endocytosis, cytokinesis, and other cellular processes. However, the mechanisms that provide tight spatiotemporal control of actin disassembly remain po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b06f4d8172f93d9a68b9e1b61b1e42
https://hal.archives-ouvertes.fr/hal-00398334