Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy

Autor: Chen Hu, Lijuan Shen, Fengming Zou, Yun Wu, Beilei Wang, Aoli Wang, Chao Wu, Li Wang, Jing Liu, Wenchao Wang, Qingsong Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 9, Pp 3694-3707 (2023)

Abnormally activated CDK9 participates in the super-enhancer mediated transcription of short-lived proteins required for cancer cell survival. Targeting CDK9 has shown potent anti-tumor activity in clinical trials among different cancers. However, th

Externí odkaz: https://doaj.org/article/449b5cfdd4f8440da8f54b1b95a6fbc7

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A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC.

Autor: Lu Y; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Fan Z; Institute of Life and Health Engineering, Jinan University, Guangzhou, China., Zhu SJ; Department of Biochemistry and Biophysics, Institute of Systems Biomedicine, Peking University Health Science Center, Beijing, China.; Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China., Huang X; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Zhuang Z; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Li Y; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Deng Z; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Gao L; Institute of Life and Health Engineering, Jinan University, Guangzhou, China., Hong X; Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Xiamen University, Xiamen, China., Zhang T; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Li L; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Sun X; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Huang W; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Zhang J; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Liu Y; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Zhang B; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Jiang J; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Gui F; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Wang Z; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Li Q; National Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China., Song S; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Huang X; Division of Drug Discovery, Hongyun Biotech Co., Ltd., Nanjing, China., Wu Q; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Chen L; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Zhou D; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Zhang J; National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Yun CH; Department of Biochemistry and Biophysics, Institute of Systems Biomedicine, Peking University Health Science Center, Beijing, China.; Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Chen L; Institute of Life and Health Engineering, Jinan University, Guangzhou, China., Deng X; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2022 Jan 11; Vol. 14 (1), pp. e14296. Date of Electronic Publication: 2021 Nov 30.