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Akademický článek

Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures

Autor: Damla Isci, Amandine Kuppens, Joshua Scalisi, Julie Cokaiko, Giulia D’Uonnolo, May Wantz, Martyna Szpakowska, Andy Chevigné, Bernard Rogister, Virginie Neirinckx

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Glioblastoma (GBM) is the most aggressive glial tumor of the adult brain, associated with invariably fatal outcome, and a deeper understanding of the underlying malignant mechanisms is necessary to address the current therapeutic failure. We

Externí odkaz: https://doaj.org/article/4a77379fdb6240419e87bd2cbc1a315a

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Akademický článek

Relationship between astrocyte damage and different levels of cerebrospinal fluid markers and prognosis in patients with subarachnoid hemorrhage

Autor: Tao Wu, Xiao He, Li Su, Xiaofeng Zhang

Publikováno v: Folia Neuropathologica, Vol 62, Iss 2, Pp 147-155 (2023)

Externí odkaz: https://doaj.org/article/4b71a7114bf34f73a5746e9f6ec3d39b

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Akademický článek

Subarachnoid hemorrhage alters CX43 and ACKR3 levels in cerebrospinal fluid: A preclinical study

Autor: Jian Yan, Dianda Chen, Jian Duan, Tao Hong

Publikováno v: Asian Journal of Surgery, Vol 46, Iss 12, Pp 6101-6102 (2023)

Externí odkaz: https://doaj.org/article/09fee60abcb74fbaa5a5df59fcd3897f

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Akademický článek

CENPF Promotes EMT in Non-small Cell Lung Cancer by Up-regulating ACKR3/CXCR7

Autor: GU Tong, JIANG Yuheng, DING Shu, CHEN Wei, LUO Chao, YU Weiyong, CHEN Xiaofei

Publikováno v: Zhongliu Fangzhi Yanjiu, Vol 49, Iss 12, Pp 1245-1251 (2022)

Objective To investigate the relationship between the expression of CENPF in NSCLC adenocarcinoma (LUAD) and the clinical prognosis of patients and its effect on the metastasis of lung adenocarcinoma cells. Methods The expression of CENPF in LUAD and

Externí odkaz: https://doaj.org/article/a38bf07fed7a4400b22202346ddbffaa

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Akademický článek

New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance

Autor: Martyna Szpakowska, Giulia D’Uonnolo, Rafael Luís, Ana Alonso Bartolomé, Marcus Thelen, Daniel F. Legler, Andy Chevigné

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands. They do, however, play a crucial regulatory role in chemokine biology by capturing, sca

Externí odkaz: https://doaj.org/article/8e49bcf050c243f79bcc7daea35cb726

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Akademický článek

ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production

Autor: Paola Antonello, Diego U. Pizzagalli, Mathilde Foglierini, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphom

Externí odkaz: https://doaj.org/article/82691c7cee7b459e96d494009acf3c8b

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