Zobrazeno 1 - 10
of 315
pro vyhledávání: '"acidocalcisome"'
Autor:
Guozhong Huang, Roberto Docampo
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 11 (2024)
ABSTRACT Acidocalcisomes of Trypanosoma brucei are membrane-bounded organelles characterized by their acidity and high content of polyphosphate and cations, like calcium and magnesium. They have important roles in cation and phosphorus storage, osmor
Externí odkaz:
https://doaj.org/article/0828871ea9f14988a6ef92feb0f4eba6
Autor:
Gustavo Benaim, Alberto Paniz-Mondolfi
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 406 (2024)
Originally developed as a chemotherapeutic agent, miltefosine (hexadecylphosphocholine) is an inhibitor of phosphatidylcholine synthesis with proven antiparasitic effects. It is the only oral drug approved for the treatment of Leishmaniasis and Ameri
Externí odkaz:
https://doaj.org/article/4aeafe2acea64a99bc1494298a2349ed
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large biosynthetic needs and detrimental bioenergetic effects of Pi. Pi homeostasis in eukaryotes uses Syg1/Pho81/Xpr1 (SPX) domains, which are receptors for inosit
Externí odkaz:
https://doaj.org/article/49445a419215412f9b344e824eef5346
Akademický článek
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Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Trypanosoma cruzi, the agent of Chagas disease, accumulates polyphosphate (polyP) and Ca2+ inside acidocalcisomes. The alkalinization of this organelle stimulates polyP hydrolysis and Ca2+ release. Here, we report that histidine ammonia lyas
Externí odkaz:
https://doaj.org/article/4ac85a070c654c3bb70929af6ebf1636
Akademický článek
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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct . 115(43), 11000-11005.
Externí odkaz:
https://www.jstor.org/stable/26532356
Autor:
Sisley Austin, Andreas Mayer
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Cells face major changes in demand for and supply of inorganic phosphate (Pi). Pi is often a limiting nutrient in the environment, particularly for plants and microorganisms. At the same time, the need for phosphate varies, establishing conflicts of
Externí odkaz:
https://doaj.org/article/077ef97be15b4cf5abd1d33276f8ed33
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Polyphosphate (polyP), a polymer of orthophosphate (PO43-) of varying lengths, has been identified in all kingdoms of life. It can serve as a source of chemical bond energy (phosphoanhydride bond) that may have been used by biological systems prior t
Externí odkaz:
https://doaj.org/article/9cd919ecc9484861a47abb5a3ab43033
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Few genetic tools were available to work with Trypanosoma cruzi until the recent introduction of the CRISPR/Cas9 technique for gene knockout, gene knock-in, gene complementation, and endogenous gene tagging. Riboswitches are naturally occurring self-
Externí odkaz:
https://doaj.org/article/2366bc7fa95e4e7395bb2a3734af04e0