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Akademický článek

Synthesis of tricarbonylated propargylamine and conversion to 2,5-disubstituted oxazole-4-carboxylates

Autor: Kento Iwai, Akari Hikasa, Kotaro Yoshioka, Shinki Tani, Kazuto Umezu, Nagatoshi Nishiwaki

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2827-2833 (2024)

The N,O-acetal derived from diethyl mesoxalate (DEMO) undergoes elimination of acetic acid upon treatment with a base, leading to the formation of N-acylimine in situ. Lithium acetylide readily attacks the imino group to afford N,1,1-tricarbonylated

Externí odkaz: https://doaj.org/article/bb5f11a54a764fffb90fe1c0a1ec65f3

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Akademický článek

Fatty acid amides present in Camembert cheese improved cognitive decline after oral administration in mice

Autor: Kohei Kawano, Maiko Shobako, Taichi Furukawa, Tatsuhiro Toyooka, Kousaku Ohinata

Publikováno v: Neuroscience Research, Vol 205, Iss , Pp 34-39 (2024)

Herein, we investigated the effects of Camembert cheese (CC) and its fatty acid contents on cognitive function in mice by employing the object recognition test to evaluate hippocampus-dependent memory. Orally administered CC improved the cognitive de

Externí odkaz: https://doaj.org/article/e22fc9d6ebc244568a7f16e5318b3068

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Akademický článek

Crystal structure and Hirshfeld surface analysis of 1-[6-bromo-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one

Autor: Anastasia A. Pronina, Alexandra G. Podrezova, Mikhail S. Grigoriev, Khudayar I. Hasanov, Nurlana D. Sadikhova, Mehmet Akkurt, Ajaya Bhattarai

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 80, Iss 7, Pp 777-782 (2024)

In the title compound, C19H18BrFN2O, the pyrrolidine ring adopts an envelope conformation. In the crystal, molecules are linked by intermolecular N—H...O, C—H...O, C—H...F and C—H...Br hydrogen bonds, forming a three-dimensional network. In a

Externí odkaz: https://doaj.org/article/a635141f89d94c6bbc5f44277b10b0ee

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Akademický článek

Crystal structure and Hirshfeld surface analysis of (Z)-4-({[2-(benzo[b]thiophen-3-yl)cyclopent-1-en-1-yl]methyl}(phenyl)amino)-4-oxobut-2-enoic acid

Autor: Elizaveta D. Yakovleva, Evgeniya R. Shelukho, Mikhail S. Grigoriev, Khudayar I. Hasanov, Nurlana D. Sadikhova, Mehmet Akkurt, Ajaya Bhattarai

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 80, Iss 5, Pp 537-542 (2024)

In the title compound, C24H21NO3S, the cyclopentene ring adopts an envelope conformation. In the crystal, molecules are linked by C—H...π interactions, forming ribbons along the a axis. Intermolecular C—H...O hydrogen bonds connect these ribbons

Externí odkaz: https://doaj.org/article/ce14eeb96b8e4cf6a49735434fc17f4f

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Akademický článek

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Akademický článek

Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors

Autor: Antonia Manduca, Valeria Buzzelli, Alessandro Rava, Alessandro Feo, Emilia Carbone, Sara Schiavi, Barbara Peruzzi, Valentina D’Oria, Marco Pezzullo, Andrea Pasquadibisceglie, Fabio Polticelli, Vincenzo Micale, Martin Kuchar, Viviana Trezza

Publikováno v: Pharmacological Research, Vol 203, Iss , Pp 107176- (2024)

Cannabidiol (CBD), a non-psychotomimetic constituent of Cannabis sativa, has been recently approved for epileptic syndromes often associated with Autism spectrum disorder (ASD). However, the putative efficacy and mechanism of action of CBD in patient

Externí odkaz: https://doaj.org/article/3f98b6a7fe6c49cfbcacdf110dfacd47

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Akademický článek

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Akademický článek

Synthesis of 2-phenyl- and 2-benzyl derivatives of 4(3Н)-quinazolinone with analgesic activity

Autor: I. P. Kodonidi, A. V. Bicherov, E. A. Manvelyan, A. A. Kolodina, A. A. Bicherov, M. M. Manvelyan, A. V. Ivchenko, N. N. Vdovenko-Martynova, A. T. Navalieva

Publikováno v: Фармация и фармакология (Пятигорск), Vol 11, Iss 1, Pp 89-100 (2023)

Quinazolin-4(3Н)-one derivatives are characterized by a wide range of pharmacological properties, among which the most significant one is a pronounced effect on the central nervous system. In this regard, a molecular design of biologically active co

Externí odkaz: https://doaj.org/article/bb209028f93e4009803ff9e16d10affe

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Akademický článek

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Akademický článek

Development issue of antiprotozoal agents to treat and prevent protozoal infections of fish, and theoretical and practical approaches to its solution

Autor: L. N. Fetisov, A. E. Svyatogorova, K. N. Kononenko, V. V. Chekrysheva, A. A. Zubenko

Publikováno v: Российский паразитологический журнал, Vol 16, Iss 3, Pp 367-376 (2022)

The purpose of the research is to determine safe parameters for the use of certain fatty acid amides against protozoal diseases of fish.Materials and methods. The synthesis and biological activity determination of new compounds were studied in labora

Externí odkaz: https://doaj.org/article/555f777e9f054f89baa2da0fd88247dc

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