Zobrazeno 1 - 10
of 25
pro vyhledávání: '"achouak achour"'
Autor:
Jian Lu, Raheel Ahmad, Thomas Nguyen, Jeffrey Cifello, Humza Hemani, Jiangyuan Li, Jinguo Chen, Siyi Li, Jing Wang, Achouak Achour, Joseph Chen, Meagan Colie, Ana Lustig, Christopher Dunn, Linda Zukley, Chee W. Chia, Irina Burd, Jun Zhu, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The characterisation of T cells during aging is important to predict functional outcomes in vaccination or infection. Here the authors use flow cytometry and scRNA sequencing to transcriptionally age CD8 T cells and then use a machine learning model
Externí odkaz:
https://doaj.org/article/06820e5848b3446782b42bbc3c749de7
Autor:
Tomokazu Amano, Hong Yu, Misa Amano, Erica Leyder, Maria Badiola, Priyanka Ray, Jiyoung Kim, Akihiro C. Ko, Achouak Achour, Nan-ping Weng, Efrat Kochba, Yotam Levin, Minoru S.H. Ko
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106335- (2023)
Summary: Intradermal delivery of self-replicating RNA (srRNA) is a promising vaccine platform. We have developed an srRNA that functions optimally at around 33°C (skin temperature) and is inactivated at or above 37°C (core body temperature) as a sa
Externí odkaz:
https://doaj.org/article/fa255e28e990463ca769c8009c863bfa
Autor:
Takenao Koseki, Mayumi Teramachi, Minako Koga, Minoru S. H. Ko, Tomokazu Amano, Hong Yu, Misa Amano, Erica Leyder, Maria Badiola, Priyanka Ray, Jiyoung Kim, Akihiro C. Ko, Achouak Achour, Nan-ping Weng, Takumi Imai, Hisako Yoshida, Satsuki Taniuchi, Ayumi Shintani, Hidetsugu Fujigaki, Masashi Kondo, Yohei Doi
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1767 (2023)
mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have played a key role in reducing morbidity and mortality from coronavirus disease 2019 (COVID-19). We conducted a double-blind, placebo-controlled phase I/II trial t
Externí odkaz:
https://doaj.org/article/18beafabbfdd4081a2b1ad576923e462
Autor:
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age. However, the precise size of human TCR repertoires, in both total and subsets of T cells,
Externí odkaz:
https://doaj.org/article/be9e3fbb629f4693b28c5ccd2679bf6e
Autor:
Xiaoping Sun, Masashi Watanabe, Baojun Zhang, Thomas Nguyen, Annette Ko, Nan-ping Weng, Alvin Shi, Achouak Achour, Yuan Zhuang, Richard J. Hodes, Qun Wang
Publikováno v:
J Immunol
Thymic regulatory T cells (tTreg) are critical in the maintenance of normal T cell immunity and tolerance. The role of TCR in tTreg selection remains incompletely understood. In this study, we assessed TCRα and TCRβ sequences of mouse tTreg and thy
Autor:
achouak achour, Xiaoping Sun, Thomas Nguyen, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyok Hiroi, Yongqing Zhang, Chia Chee, William Wood, Wells Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rongfong Shen, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
The Journal of Immunology. 206:98.16-98.16
A competent T-cell receptor (TCR) repertoire contains TCRs recognizing both novel and experienced antigens. It is widely believed that the human TCR repertoire declines with age, but its precise change in size and clonal distribution with age has not
Autor:
Achouak Achour, Audrey Mohr, Quentin Simon, Ibtissem Ghedira, Boutahar Bendaoud, Pierre Youinou, Christophe Jamin, Jean-François Séité, Jacques-Olivier Pers
Publikováno v:
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2017, ⟨10.1016/j.jaci.2016.09.042⟩
Journal of Allergy and Clinical Immunology, Elsevier, 2017, ⟨10.1016/j.jaci.2016.09.042⟩
Background Follicular helper T (T FH ) cells support terminal B-cell differentiation. Human regulatory B (Breg) cells modulate cellular responses, but their control of T FH cell–dependent humoral immune responses is unknown. Objective We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b87e4d9b9c3756e77c22d1181feb208
https://hal.archives-ouvertes.fr/hal-01492613
https://hal.archives-ouvertes.fr/hal-01492613
Publikováno v:
La Presse Médicale
La Presse Médicale, Elsevier Masson, 2014, 43 (1), pp.18-26
La Presse Médicale, Elsevier Masson, 2014, 43 (1), pp.18-26
Mechanims of peripheral tolerance include molecular controls and the presence of regulatory lymphocytes. Regulatory T lymphocytes (Tregs) correspond to different sub-populations of T cells that control immune responses due to the production of cytoki
Autor:
achouak achour, Guobing Chen, Alexei Sharov, Thomas Nguyen, Xiang Li, Michael Patrick, William Wood, Supriyo De, Kevin Becker, Weiqun Peng, Nan-Ping Weng
Publikováno v:
The Journal of Immunology. 202:65.14-65.14
Aging of immune system is characterized by progressive decline of physiological and cellular function of T cells, leading to a reduced immune function in the old. Recent studies of naïve T cells from young and old mice have identified age-related al
Publikováno v:
Endocrine Research. 38:98-104
Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease, but they had also been found in many other autoimmune diseases.The aim of this study was to evaluate the prevalence of ASCA in patients with autoimmune