NAT2 Slow Acetylator Phenotype as a Significant Risk Factor for Hepatotoxicity Caused by Antituberculosis Drugs: Results From a Multiethnic Nested Case-Control Study.

Autor: Cheli S; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy., Torre A; III Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy., Schiuma M; II Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy., Montrasio C; Center of Functional Genomics and Rare Diseases, Buzzi Children's Hospital, Milan, Italy., Civati A; Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Milan, Italy., Galimberti M; Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Milan, Italy., Battini V; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy., Mariani I; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy., Mosini G; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy., Carnovale C; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy., Radice S; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy., Clementi E; ICPS, Pharmacovigilance & Clinical Research, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University Hospital Luigi Sacco, Università Degli Studi di Milano, Milan, Italy.; III Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.; II Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.; Center of Functional Genomics and Rare Diseases, Buzzi Children's Hospital, Milan, Italy.; Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Milan, Italy.; Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy., Gori A; II Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.; Center of Functional Genomics and Rare Diseases, Buzzi Children's Hospital, Milan, Italy.; Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Milan, Italy., Antinori S; III Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.; II Infectious Disease Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.; Center of Functional Genomics and Rare Diseases, Buzzi Children's Hospital, Milan, Italy.; Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Milan, Italy.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Dec 27. Date of Electronic Publication: 2024 Dec 27.

Importance of Acetylator Phenotype in the Identity of Asian Populations

Autor: ZAID, R. B., NARGIS, M., NEELOTPOL, S., SAYEED, M. A., BANU, A., SHUROVI, S., HASSAN, K. N., SALIMULLAH, M., ALI, L., KHAN, A. K. AZAD

Publikováno v: Human Biology, 2007 Jun 01. 79(3), 363-368.

Externí odkaz: https://www.jstor.org/stable/41466490

Clinical Prediction of Acetylator Phenotype in Tuberculosis Patients on Medicare using Blood Group

Autor: J. P. MAIRIGA, M.C. UKEAGBU, L. J. AMBI

Publikováno v: Journal of Current Biomedical Research. 2:289-298

Individual acetylation phenotype detected by metabolic phenotyping tests using a number of surrogate drugs, such as isoniazid is time consuming. The aim of this work was to determine the clinical prediction of acetylator phenotype in tuberculosis pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3d9b3b64bbbce2987840b819ab624db
https://doi.org/10.54117/jcbr.v2i4.4

Variants in the N-acetyltranferase 2 gene, acetylator phenotypes and their association with tuberculosis: Findings in Peruvian patients

Autor: Rodrigo Sánchez, Oscar Acosta, Lina Laymito, Teodoro Oscanoa, María Guevara-Fujita, Saul Moscol, Daisy Obispo, Doris Huerta, Ricardo Fujita

Publikováno v: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 37, Iss , Pp 100485- (2024)

Background: Tuberculosis (TB) is a highly prevalent chronic infectious disease in developing countries, with Peru being one of the most affected countries in the world. The variants of the N-acetyltransferase 2 (NAT2) gene are related to xenobiotic m

Externí odkaz: https://doaj.org/article/f289019498cc442c9f1b06355859e3af

Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment.

Autor: Eisenhut, Michael¹ michael_eisenhut@yahoo.com, Thieme, Detlef², Schmid, Dagmar³, Fieseler, Sybille³, Sachs, Hans²

Publikováno v: Tuberculosis Research & Treatment. 2012, p1-6. 6p. 5 Graphs.