Zobrazeno 1 - 10
of 3 173
pro vyhledávání: '"abscopal"'
Autor:
Júlia Moscardini-Martelli, Alejandro Rodríguez-Camacho, Jorge Alejandro Torres-Ríos, Juan Marcos Meraz-Soto, José Guillermo Flores-Vázquez, Laura Crystell Hernández-Sánchez, Francisco Javier Lozano-Ruiz, Federico Maldonado-Magos, Dharely Cid-Sánchez, Christian Haydeé Flores-Balcázar, Miguel Ángel Celis-López, Guillermo Axayacatl Gutiérrez-Aceves, Fabiola Flores-Vázquez, Sergio Moreno-Jiménez
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 10, Pp 11075-11085 (2024)
Seventy years ago, Robin Mole introduced the concept of the abscopal effect to describe a rare phenomenon. This occurs when local radiation triggers an immune-mediated reduction in tumors outside the treated area but within the same organism. Observi
Externí odkaz:
https://doaj.org/article/209daaf061c0465ca4780fe61fb29c35
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Radiotherapy (RT) controls local lesions, meantime it has the capability to induce systemic response to inhibit distant, metastatic, non-radiated tumors, which is referred to as the “abscopal effect”. It is widely recognized that radioth
Externí odkaz:
https://doaj.org/article/aa020035844b4b7bb900c1f4e3ad339c
Autor:
Kewen He, Nahum Puebla-Osorio, Hampartsoum B. Barsoumian, Duygu Sezen, Zahid Rafiq, Thomas S. Riad, Yun Hu, Ailing Huang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Lily Jae Schuda, Ethan Hsu, Joshua Heiber, Maria-Angelica Cortez, James W. Welsh
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background Combining interleukin-2 (IL-2) with radiotherapy (RT) and immune checkpoint blockade (ICB) has emerged as a promising approach to address ICB resistance. However, conventional IL-2 cytokine therapy faces constraints owing to its b
Externí odkaz:
https://doaj.org/article/d5dfdad3aeaf4ef7a03ae6638ec04617
Autor:
Vishali Moond, Bhumi Maniyar, Prateek Suresh Harne, Jennifer M. Bailey-Lundberg, Nirav C. Thosani
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 5, Pp 1056-1073 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognostics and substantial therapeutic challenges, with dismal survival rates. Tumor resistance in PDAC is primarily attributed to its fibrotic, hypoxic, and immune-suppressive tumor m
Externí odkaz:
https://doaj.org/article/af71d80df71c4d0aa68cc789a7429f23
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant unirradiated tumors (abscopal effect); however, the results are still not very satisfactory.
Externí odkaz:
https://doaj.org/article/0e3b46e589f74c6784ae1b2936175882
Publikováno v:
Cancer Communications, Vol 44, Iss 7, Pp 739-760 (2024)
Abstract Immunotherapy, particularly with immune checkpoint inhibitors, has significantly transformed cancer treatment. Despite its success, many patients struggle to respond adequately or sustain long‐lasting clinical improvement. A growing consen
Externí odkaz:
https://doaj.org/article/85912ae7e92543419e0557cbeeca5c02
Publikováno v:
陆军军医大学学报, Vol 46, Iss 13, Pp 1477-1486 (2024)
Objective To explore the sensitizing effect of manganese for radiotherapy against tumors and its possible mechanisms. Methods A total of 300 male C57BL/6 mice (6~8 weeks old, weighing 20~23 g) with subcutaneous tumor were randomly divided into 4 grou
Externí odkaz:
https://doaj.org/article/c06e0e6784c34c7589ce2a1666cebf1b
Publikováno v:
EJC Skin Cancer, Vol 2, Iss , Pp 100258- (2024)
Anti-PD-1 monoclonal antibodies have improved outcomes of advanced melanoma patients, but improved strategies are warranted. Some melanoma studies suggest the efficacy of radiotherapy combined with anti-PD-1, but its place in melanoma care is debated
Externí odkaz:
https://doaj.org/article/a7fcee3757464bcfb759a15ca6d35abb
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe abscopal effect, a systemic anti-tumor response triggered by localized treatment, has gained attention but remains poorly understood. This study evaluates the efficacy and consistency of focused ultrasound (FUS) combined with immunoth
Externí odkaz:
https://doaj.org/article/c14a018d1ccf4ef78916ff95e09047ba
Autor:
Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Ramdane Guemiri, Andrew Boone, Deborah Bellet, Brianna Rivest, James Cardia, Caroline Robert, Simon P. Fricker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveImmunotherapeutic inhibition of PD-1 by systemically administered monoclonal antibodies is widely used in cancer treatment, but it may cause severe immune-related adverse events (irSAEs). Neoadjuvant PD-1 inhibition before surgery has shown
Externí odkaz:
https://doaj.org/article/4c11e064c3e94d87ae9030c00767206b