Zobrazeno 1 - 10
of 8 042
pro vyhledávání: '"abcg2"'
Autor:
Ke Song, Xiangxin Kong, Zhongyang Zhang, Yin Xian, Ming He, Yuan Zhang, Xinxin Liao, Ziyan Huang, Aijia Kang, Dingqi Xiao, Yixing Ren
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Hyperuricemic nephropathy (HN) is renal injury caused by hyperuricemia (HUA). While sleeve gastrectomy (SG) has shown promise in improving renal injury in patients with obesity-related HN, the mechanisms are not fully understood. This study
Externí odkaz:
https://doaj.org/article/ddea8e7a19064db1a64ad233ec9d8652
Autor:
Aristeidis Lentzas, Mark C. de Gooijer, Stefanie Zuidema, Amber Meurs, Ceren H. Çitirikkaya, Nikkie Venekamp, Jos H. Beijnen, Olaf van Tellingen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Pharmacotherapy for brain diseases is severely compromised by the blood-brain barrier (BBB). ABCB1 and ABCG2 are drug transporters that restrict drug entry into the brain and their inhibition can be used as a strategy to boost dru
Externí odkaz:
https://doaj.org/article/57eb6677d2ba47b88093983f8eec384d
Autor:
Bing-Huan Lin, Yen-Ching Li, Megumi Murakami, Yu-Shan Wu, Yang-Hui Huang, Tai-Ho Hung, Suresh.V. Ambudkar, Chung-Pu Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117542- (2024)
A significant hurdle in cancer treatment arises from multidrug resistance (MDR), often due to overexpression of ATP-binding cassette (ABC) transporters like ABCB1 and/or ABCG2 in cancer cells. These transporters actively diminish the efficacy of cyto
Externí odkaz:
https://doaj.org/article/704b71edd5c043f7a3fb501d725d7c37
Autor:
Yen-Ching Li, Yun-Chieh Lee, Megumi Murakami, Yang-Hui Huang, Tai-Ho Hung, Yu-Shan Wu, Suresh.V. Ambudkar, Chung-Pu Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117554- (2024)
Chemotherapy treatment faces a major obstacle with the emergence of multidrug resistance (MDR), often attributed to the elevated expression of ATP-binding cassette (ABC) transporters such as ABCG2 and ABCB1 in cancer cells. These transporters hinder
Externí odkaz:
https://doaj.org/article/6ab91c456db54964b09cd565d19b7546
Publikováno v:
Kidney Medicine, Vol 6, Iss 11, Pp 100896- (2024)
Rationale & Objective: Allopurinol and febuxostat, which are xanthine oxidoreductase inhibitors, have been widely used as uric acid-lowering medications. However, evidence regarding their cardiovascular effects in hemodialysis is insufficient. This s
Externí odkaz:
https://doaj.org/article/339cbec8a00740ddb01c5984b332a710
Autor:
Belén García-Fariña, Lydia Rink, Virginia Santarini, Marco Westkemper, Christian Dohna-Schwake, Birte Möhlendick
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimsA number of case reports have documented the occurrence of acute hepatic and renal toxicity during treatment with deferasirox (DFX). The precise mechanisms underlying these adverse events remain unclear, with the time to toxicity v
Externí odkaz:
https://doaj.org/article/abda4726993243e0b7907c7145ae5a24
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37839- (2024)
Background: Serum uric acid (SUA) is an important predictor of cardiovascular events and mortality. The ABCG2 rs2231142 variant (TT genotype) is associated with hyperuricemia (HUA), but the relationship between ABCG2 gene polymorphisms and coronary a
Externí odkaz:
https://doaj.org/article/a6a44fb5470846c9b957690e2b761bad
Autor:
Chang Li, Yi Cai, Yongmin Chen, Jingyi Tong, Youbin Li, Dong Liu, Yun Wang, Zhiping Li, Yan Wang, Qifu Li
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103262- (2024)
The transporter protein ABC subfamily G member 2 (ABCG2) is implicated in epilepsy; however, its specific role remains unclear. In this study, we assessed changes in ABCG2 expression and its role in epilepsy both in vitro and in vivo. We observed an
Externí odkaz:
https://doaj.org/article/e3eb5ac1d0f94c7ebb8fac94c57e9853
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant los
Externí odkaz:
https://doaj.org/article/06dbe264636040fc80d80e175a11685e
Autor:
Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background A principal protective component of the mammalian blood–brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface
Externí odkaz:
https://doaj.org/article/9a080e0214994889a3107bc9b1dea9d1