Zobrazeno 1 - 10
of 861
pro vyhledávání: '"abasic site"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background We recently developed two high-resolution methods for genome-wide mapping of two prominent types of DNA damage, single-strand DNA breaks (SSBs) and abasic (AP) sites and found highly complex and non-random patterns of these lesion
Externí odkaz:
https://doaj.org/article/cb42d8e347ca4d26b7f8c497150a21e8
Publikováno v:
Chemistry, Vol 5, Iss 3, Pp 1497-1507 (2023)
DNAzymes have attracted increasing interest in developments of gene tools, therapies, and biosensors. Among them, G-quadruplexes are widely used as the key structure elements of DNAzymes to activate the catalytic competency of specific cofactors, suc
Externí odkaz:
https://doaj.org/article/fda496034f354b899839890aa5c97711
Autor:
Peng Lu, Xiangjian Cao, Jinghui Zheng, Chenxv Zhu, Ruilan Zhang, Ying Sun, Ziyu Yang, Ziyu Tang, Jiayu Wang, Meiping Zhao
Publikováno v:
Biosensors and Bioelectronics: X, Vol 14, Iss , Pp 100329- (2023)
As a multifunctional DNA repair enzyme, human apurinic/apyrimidinic endonuclease 1 (APE1) plays a pivotal role in many cellular processes. In recent years, it has been recognized as a potential prognostic biomarker and a therapeutic target for many c
Externí odkaz:
https://doaj.org/article/bab3d95ac127475ca28885b6aef81df5
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Xu Feng, Baochang Zhang, Ruyi Xu, Zhe Gao, Xiaotong Liu, Guanhua Yuan, Sonoko Ishino, Mingxia Feng, Yulong Shen, Yoshizumi Ishino, Qunxin She
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Abasic sites are among the most abundant DNA lesions encountered by cells. Their replication requires actions of specialized DNA polymerases. Herein, two archaeal specialized DNA polymerases were examined for their capability to perform translesion D
Externí odkaz:
https://doaj.org/article/50fc8701a338457ea6fe3d63c6cda331
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-8 (2018)
Abstract Background Abasic sites are formed spontaneously and by nucleobase chemical modifications and base excision repair. A chemically stable abasic site analog was site-specifically introduced into replicable plasmid DNAs, which were transfected
Externí odkaz:
https://doaj.org/article/c003238363624ae88ef67e1166677ea9
Autor:
Mikiei Tanaka, P. Boon Chock
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Elevated level of oxidized RNA was detected in vulnerable neurons in Alzheimer patients. Subsequently, several diseases and pathological conditions were reported to be associated with RNA oxidation. In addition to several oxidized derivatives, cross-
Externí odkaz:
https://doaj.org/article/28802213580641b789a6320ab4314016
Autor:
Anastasiia T. Davletgildeeva, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Despite significant achievements in the elucidation of the nature of protein-DNA contacts that control the specificity of nucleotide incision repair (NIR) by apurinic/apyrimidinic (AP) endonucleases, the question on how a given nucleotide is accommod
Externí odkaz:
https://doaj.org/article/5d3b6b0228094489b314ed71f7317e66