Zobrazeno 1 - 10
of 10 795
pro vyhledávání: '"aav"'
Autor:
Liang Xu, Shun Yao, Yifan Evan Ding, Mengxiao Xie, Dingqi Feng, Pengfei Sha, Lu Tan, Fengfeng Bei, Yizheng Yao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Recombinant adeno-associated viruses (rAAVs) have emerged as an attractive tool for gene delivery, and demonstrated tremendous promise in gene therapy and gene editing—therapeutic modalities with potential “one-and-done” treatment bene
Externí odkaz:
https://doaj.org/article/7c73267eba20444eb8bd9438bf24822a
Autor:
Monika Chauhan, Audrey L. Daugherty, Fatemeh (Ellie) Khadir, Ozgun F. Duzenli, Alexandra Hoffman, Jennifer A. Tinklenberg, Peter B. Kang, George Aslanidi, Christina A. Pacak
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Highly efficient adeno associated viruses (AAVs) targeting the central nervous system (CNS) are needed to deliver safe and effective therapies for inherited neurological disorders. The goal of this study was to compare the organ-specific tra
Externí odkaz:
https://doaj.org/article/cafeb29b8b2c4e6c854217899ac3adad
Autor:
D. S. Leontyev, F. A. Urusov, D. V. Glazkova, B. V. Belugin, O. V. Orlova, R. R. Mintaev, G. M. Tsyganova, E. V. Bogoslovskaya, G. A. Shipulin
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 3, Pp 312-321 (2024)
INTRODUCTION. Despite existing treatment methods, complete eradication of human immunodeficiency virus (HIV) infection remains an unattainable goal due to the high variability of HIV type 1 (HIV-1). HIV infection necessitates life-long administration
Externí odkaz:
https://doaj.org/article/b076f82274424b8192a6f8cb79b849bc
Autor:
Melanie Herre, Kalyani Vemuri, Jessica Cedervall, Stefanie Nissl, Falk Saupe, Jacob Micallef, Henrik Lindman, Casey A. Maguire, George Tetz, Victor Tetz, Anna‐Karin Olsson
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 10, Pp 454-466 (2024)
Abstract Neutrophil extracellular traps (NETs) have been implicated in the pathology of various inflammatory conditions. In cancer, NETs have been demonstrated to induce systemic inflammation, impair peripheral vessel and organ function and promote m
Externí odkaz:
https://doaj.org/article/60eac28cad7e4664b5ec44156895a97e
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-9 (2024)
Abstract Neurodegenerative diseases pose a significant health burden globally, with limited treatment options available. Among the various cell types involved in the pathogenesis of these disorders, microglia, the resident immune cells of the central
Externí odkaz:
https://doaj.org/article/d55e32784f37458694afecbf71f262e1
Autor:
Meng-Qi Dong, Yuan Xie, Zhi-Liang Tang, Xue-Wen Zhao, Fu-Zhen Lin, Guang-Yu Zhang, Zhi-Hao Huang, Zhi-Min Liu, Yuan Lin, Feng-Yong Liu, Wei-Jie Zhou
Publikováno v:
Liver Research, Vol 8, Iss 3, Pp 165-171 (2024)
Background and aim: Hepatic ischemia–reperfusion injury (IRI) is a significant challenge in liver transplantation, trauma, hypovolemic shock, and hepatectomy, with limited effective interventions available. This study aimed to investigate the role
Externí odkaz:
https://doaj.org/article/a1b8e730d358405c822d3f35b512507a
Autor:
Petr Nickl, Irena Jenickova, Jan Elias, Petr Kasparek, Cyril Barinka, Jana Kopkanova, Radislav Sedlacek
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Site-specific recombinases (SSRs) are critical for achieving precise spatiotemporal control of engineered alleles. These enzymes play a key role in facilitating the deletion or inversion of loci flanked by recombination sites, resulting in t
Externí odkaz:
https://doaj.org/article/79cca0ad81ff48a8a1b67a0712663e5a
Autor:
Joonwoo Rhee, Jong‐Seol Kang, Young‐Woo Jo, Kyusang Yoo, Ye Lynne Kim, Sang‐Hyeon Hann, Yea‐Eun Kim, Hyun Kim, Ji‐Hoon Kim, Young‐Yun Kong
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1404-1417 (2024)
Abstract Background Zolgensma is a gene‐replacement therapy that has led to a promising treatment for spinal muscular atrophy (SMA). However, clinical trials of Zolgensma have raised two major concerns: insufficient therapeutic effects and adverse
Externí odkaz:
https://doaj.org/article/a56693d68b7f4f60bf7ae75f4aeebea6
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 123-139 (2024)
INTRODICTION. Currently, gene therapy based on adeno-associated virus (AAV) vectors faces a number of barriers, both biomedical and technological, which require studying and overcoming for further development of this gene therapy technology.AIM. This
Externí odkaz:
https://doaj.org/article/71be6780a74542e89f7c57e1138ef4ad
Autor:
D. O. Maksimov, D. A. Naumova, E. A. Astakhova, V. V. Artemev, S. A. Biryukov, I. S. Abramov, A. A. Navoikova, N. V. Rudev, S. G. Feoktistova, O. V. Glazova, O. N. Mityaeva, P. Yu. Volchkov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 215-228 (2024)
INTRODUCTION. The creation of synthetic adeno-associated virus (AAV) vectors during gene therapy development is a labour-intensive and expensive process. The optimal solution to minimise the time and costs associated with gene therapy development lie
Externí odkaz:
https://doaj.org/article/ca88668e6b554917a47143e75b0e751a