Zobrazeno 1 - 10
of 88
pro vyhledávání: '"a and Gary D. Brayer"'
Autor:
Christina Tysoe, Leslie K. Williams, Robert Keyzers, Nham T. Nguyen, Chris Tarling, Jacqueline Wicki, Ethan D. Goddard-Borger, Adeleke H. Aguda, Suzanne Perry, Leonard J. Foster, Raymond J. Andersen, Gary D. Brayer, Stephen G. Withers
Publikováno v:
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Externí odkaz:
https://doaj.org/article/ba205bf08fcc4bb4a7ca9db931de6034
Autor:
Fuqiang Ban, Evgenia V. Dueva, Takeshi Yamazaki, Nada Lallous, Nader Al Nakouzi, Martin E. Gleave, Amina Zoubeidi, Susan C. Moore, Nham T. Nguyen, Fan Zhang, Neetu Saxena, Sophie M. Stief, Lucia Nappi, Dulguun Battsogt, Eliana Beraldi, Marisa Thi, Barbara Lelj-Garolla, Artem Cherkasov, Adeleke H Aguda, Gary D. Brayer, Ladan Fazli
Publikováno v:
J Clin Invest
HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structure-gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e7e5717c173cfc68e7cf7ebb1f87e5
https://pubmed.ncbi.nlm.nih.gov/31845908
https://pubmed.ncbi.nlm.nih.gov/31845908
Autor:
Christina R. Tysoe, Sami Caner, Matthew B. Calvert, Anna Win-Mason, Gary D. Brayer, Stephen G. Withers
Publikováno v:
Chemical Science
Simplified analogues of montbretin A bind similarly to human alpha amylase and with nanomolar affinity.
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, KI = 60 and 70 nM, with i
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, KI = 60 and 70 nM, with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18982f3cc8fb86724cbae779804f55d2
https://pubmed.ncbi.nlm.nih.gov/32206255
https://pubmed.ncbi.nlm.nih.gov/32206255
Publikováno v:
Biochemistry. 55:6000-6009
Starch provides the major source of caloric intake in many diets. Cleavage of starch into malto-oligosaccharides in the gut is catalyzed by pancreatic α-amylase. These oligosaccharides are then further cleaved by gut wall α-glucosidases to release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4493d7815e58f57275eb511267b2b46
https://doi.org/10.1021/acs.biochem.6b00992
https://doi.org/10.1021/acs.biochem.6b00992
Autor:
Adeleke Aguda, Leonard J. Foster, Jacqueline Wicki, Ethan D. Goddard-Borger, Gary D. Brayer, Christina Tysoe, Robert A. Keyzers, Stephen G. Withers, Leslie K. Williams, Nham T. Nguyen, Raymond J. Andersen, Suzanne Perry, Chris A. Tarling
Publikováno v:
ACS Central Science
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Selective inhibitors of human pancreatic α-amylase (HPA) are an effective means of controlling blood sugar levels in the management of diabetes. A high-throughput screen of marine natural product extracts led to the identification of a potent (Ki =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2203587f5c05ee5fe8629b52e661e5
http://europepmc.org/articles/PMC4819454
http://europepmc.org/articles/PMC4819454
Autor:
David E. Williams, Jacqueline Wicki, Gary D. Brayer, Coleman John, Leslie K. Williams, Stephen G. Withers, Nham T. Nguyen, Raymond J. Andersen, Violet G. Yuen, Xiaohua Zhang, Sami Caner, John H. McNeill, Christina Tysoe
Publikováno v:
Nature Chemical Biology. 11:691-696
The complex plant flavonol glycoside montbretin A is a potent (Ki = 8 nM) and specific inhibitor of human pancreatic α-amylase with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae166e64668f81caf292fcc5b366489b
https://doi.org/10.1038/nchembio.1865
https://doi.org/10.1038/nchembio.1865
Autor:
Harry W. Duckworth, Ayeda Ayed, Lynda J. Donald, Brigitte Bruneau, Yin Gao, Nham T. Nguyen, Gary D. Brayer, Robert Maurus
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:2546-2553
The citrate synthase (CS) of Escherichia coli is an allosteric hexameric enzyme specifically inhibited by NADH. The crystal structure of wild type (WT) E. coli CS, determined by us previously, has no substrates bound, and part of the active site is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6166b69c7d04bb32e2a48f66202ed862
https://doi.org/10.1016/j.bbapap.2013.07.019
https://doi.org/10.1016/j.bbapap.2013.07.019
Autor:
Natasha Kruglyak, Simon Law, Nham T. Nguyen, Pierre-Marie Andrault, Adeleke Aguda, Gary D. Brayer, Dieter Brömme
Publikováno v:
The Biochemical journal. 474(5)
Cathepsin K (CatK) is the predominant mammalian bone-degrading protease and thus an ideal target for antiosteoporotic drug development. Rodent models of osteoporosis are preferred due to their close reflection of the human disease and their ease of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528f8124f48a3617ed134c2be566f2bf
https://pubmed.ncbi.nlm.nih.gov/28049758
https://pubmed.ncbi.nlm.nih.gov/28049758
Publikováno v:
Journal of Medicinal Chemistry. 55:10177-10186
The increasing prevalence of diabetes has accelerated the search for new drugs derived from natural sources. To define the functional features of two such families of compounds, the flavonols and the ethyl caffeates, we have determined the high-resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce5744fbf8912c393e09d0b866b858e
https://doi.org/10.1021/jm301273u
https://doi.org/10.1021/jm301273u
Autor:
Robert Maurus, Meriem Alami, Jennifer Tan, Franck Duong, Stephen S. Sligar, Woo Cheol Lee, Nham T. Nguyen, Gary D. Brayer, Kush Dalal, Trevor F. Moraes
Publikováno v:
Journal of Biological Chemistry. 284:7897-7902
The Syd protein has been implicated in the Sec-dependent transport of polypeptides across the bacterial inner membrane. Using Nanodiscs, we here provide direct evidence that Syd binds the SecY complex, and we demonstrate that interaction involves the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf40331ac8d97348b9e625e2fbca2b1
https://doi.org/10.1074/jbc.m808305200
https://doi.org/10.1074/jbc.m808305200