Zobrazeno 1 - 10
of 969
pro vyhledávání: '"aβ42"'
Autor:
Wei Yang, Fulin Guan, Lihui Yang, Guangli Shou, Fangfang Zhu, Yuanyuan Xu, Ying Meng, Min Li, Wanli Dong
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundPlasma biomarker has the potential to be the reliable and propagable approach in the early stage diagnosis of Alzheimer’s disease (AD). However, conventional methods appear powerless in the detection of these biomarkers at low concentrati
Externí odkaz:
https://doaj.org/article/22221f7e8c804868b78652afe286873e
Autor:
Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sawanya Charoenlappanit, Siriwan Thaisakun, Nitithorn Kumsri, Teerakul Arpornsuwan
Publikováno v:
PeerJ, Vol 12, p e17732 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disease that causes physical damage to neuronal connections, leading to brain atrophy. This disruption of synaptic connections results in mild to severe cognitive impairments. Unfortunately, no effect
Externí odkaz:
https://doaj.org/article/36b7042dd8b948d79601564e30c866b9
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this question by assessing the
Externí odkaz:
https://doaj.org/article/9151a3a18aa041a7a311fdf3ba5f8463
Autor:
Lijiao Zu, Xicheng Wang, Peng Liu, Jiwei Xie, Xuejun Zhang, Weiru Liu, Zhencheng Li, Shiqing Zhang, Kaiwei Li, Ambra Giannetti, Wei Bi, Francesco Chiavaioli, Lei Shi, Tuan Guo
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract As the population ages, the worldwide prevalence of Alzheimer's disease (AD) as the most common dementia in the elderly is increasing dramatically. However, a long‐term challenge is to achieve rapid and accurate early diagnosis of AD by de
Externí odkaz:
https://doaj.org/article/679509fdfefc4426950175a39e497a19
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e26832- (2024)
Alzheimer's disease is the most common form of dementia and is characterized by cognitive impairment. The disruption of autophagosome-lysosome function has been linked to the pathogenesis of Alzheimer's disease. Tris (1,3-dichloro-2-propyl) phosphate
Externí odkaz:
https://doaj.org/article/bf770970c4424930a116a5f0757f1b44
Autor:
Brianna Cyr, Rosie Curiel Cid, David Loewenstein, Regina T. Vontell, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7758 (2024)
Dementia is a group of symptoms including memory loss, language difficulties, and other types of cognitive and functional impairments that affects 57 million people worldwide, with the incidence expected to double by 2040. Therefore, there is an unme
Externí odkaz:
https://doaj.org/article/bd0319cd8e61414ea2871f38e20c35ef
Autor:
Kecheng Li, Xiaoli Zhou, Youren Liu, Dongyu Li, Yinyin Li, Ting Zhang, Chunyan Fu, Lin Li, Yang Hu, Li Jiang
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β peptides
Externí odkaz:
https://doaj.org/article/002da5fb74d7409c94d7817c56fb1f74
Publikováno v:
Metabolites, Vol 14, Iss 7, p 369 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disease. Mitochondrial energy metabolism and p70 ribosomal protein S6 kinase (p70S6K) play significant roles in AD pathology. However, the potential relationship between them is unclear. In this study
Externí odkaz:
https://doaj.org/article/3d9265d833e14f51803d0657bfccd303
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6401 (2024)
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer’s disease, the major cause of late-age dementia. The mechanisms of A
Externí odkaz:
https://doaj.org/article/8eeda6a1d85b45ee9a2523cb75cef6e5
Publikováno v:
International Journal of General Medicine, Vol Volume 16, Pp 2573-2583 (2023)
ZeYu Xu,1,* Ou Li,1,* YaTing Liang,1,* ZhiBing Wu,2 Jiamei Xu,2 Ling Wang,3 Ling Li,3 YongNing Sun1 1Department of Brain and Mental Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional C
Externí odkaz:
https://doaj.org/article/27ff0c8a29e64a1dbceb75e44de2c94d