Zobrazeno 1 - 10
of 10 997
pro vyhledávání: '"aβ"'
Publikováno v:
Ibrain, Vol 10, Iss 3, Pp 266-289 (2024)
Abstract Amyloid‐β (Aβ) is a pivotal biomarker in Alzheimer's disease (AD), attracting considerable attention from numerous researchers. There is uncertainty regarding whether clearing Aβ is beneficial or harmful to cognitive function. This ques
Externí odkaz:
https://doaj.org/article/0b9a66f48d0b45adbbfc539b4caefb95
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive dysfunction in older adults. One of the AD pathological factors, β-Amyloid (Aβ), triggers inflammatory responses and phagocytosis of microglia. C-ty
Externí odkaz:
https://doaj.org/article/8fec39495d024e938bed4c6fc44d369b
Autor:
Marlene Pils, Alexandra Dybala, Anja Schaffrath, Fabian Rehn, Janine Kutzsche, Lara Blömeke, Markus Tusche, Pelin Özdüzenciler, Tuyen Bujnicki, Victoria Kraemer-Schulien, Hannes Gramespacher, Maximilian H.T. Schmieschek, Michael T. Barbe, Oezguer A. Onur, Gereon R. Fink, Gültekin Tamgüney, Oliver Bannach, Dieter Willbold
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Misfolding and aggregation of amyloid β (Aβ), along with neurofibrillary tangles consisting of aggregated Tau species, are pathological hallmarks of Alzheimer’s disease (AD) onset and progression. In this study, we hypothesize
Externí odkaz:
https://doaj.org/article/b0b02792593c44ceb0604023450e40a8
Autor:
Yaru Yang, Hongyan Qiu, Yuru Fan, Qin Zhang, Huiling Qin, Juan Wu, Xuan Zhang, Yueyue Liu, Renpeng Zhou, Qian Zhang, Zi Ye, Jingyue Ma, Ye Xu, Sheng Feng, Yue Fei, Na Li, Xiaojing Cui, Fangli Dong, Quanren Wang, Kai Shen, Sepehr Shakib, Jasmine Williams, Wei Hu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background SHR-1707 is a novel humanized anti-Aβ IgG1 monoclonal antibody that binds to Aβ fibrils and monomers to block the formation of Aβ plaques or to promote the microglial phagocytosis of Aβ. Preclinical studies showed that SHR-170
Externí odkaz:
https://doaj.org/article/c235061a1161431ba736e7493e4d3bee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, impacting millions of individuals worldwide. Among its defining characteristics is the accumulation of senile plaques within the brain’s gray matter, formed through the
Externí odkaz:
https://doaj.org/article/a0b90e2264c6434b9dcf4a455fe28914
Autor:
Jeonghun Kim, Sang-Il Suh, Yu Jeong Park, Minwoong Kang, Su Jin Chung, Eun Seong Lee, Hye Na Jung, Jae Seon Eo, Seong-Beom Koh, Kyungmi Oh, Sung Hoon Kang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Low body mass index is closely related to a high risk of Alzheimer’s disease (AD) and related biomarkers including amyloid-β (Aβ) deposition. However, the association between sarcopenia and Aβ-confirmed AD remains controversial. Therefo
Externí odkaz:
https://doaj.org/article/89ec1166ba734c9b8b6762f252849c4e
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Autor:
Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi Hwang, Junghee Lee, C. Justin Lee, Hoon Ryu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell aut
Externí odkaz:
https://doaj.org/article/10d1c6d648c04589a8cf3caf530fc135
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 688-699 (2024)
The self-assembly of Aβ peptides into toxic oligomers and fibrils is the primary cause of Alzheimer's disease. Moreover, the conformational transition from helix to sheet is considered a crucial step in the aggregation of Aβ peptides. However, the
Externí odkaz:
https://doaj.org/article/163960479b0a424092b958f55da83817
Publikováno v:
Computational and Mathematical Biophysics, Vol 12, Iss 1, Pp 2152-2161 (2024)
Alzheimer’s disease is one of the most prevalent types of dementia worldwide. It is caused by the accumulation of amyloid-beta (Aβ) plaques in the brain, disrupting communication pathways and memory. Microglia and astrocytes act as the immune syst
Externí odkaz:
https://doaj.org/article/8c3ff0c7ac8b47a1b6704a5e9e8ea2a4
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer disease (AD) is a heterogenous and multifactorial disease, and its pathology is partly driven by microglia and their activated phenotype. Brain organoids (BOs) are gaining prominence as a relevant model of the human brai
Externí odkaz:
https://doaj.org/article/42fb4bcc72914191ac8dbebc4e321cdf