Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Zygmunt S. Krozowski"'
Autor:
Alicia N Stein-Oakley, Zygmunt S. Krozowski, John E. Dowling, Napier M. Thomson, Julie A. Maguire, Greg J. Perry
Publikováno v:
Nephrology. 4:81-86
SUMMARY: The enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2) converts glucocorticoids to their 11-keto metabolites, permitting binding of aldosterone to the non-selective mineralocorticoid receptor. Recent studies have suggested that 11βH
Autor:
Damian G. Romero, Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez, Zygmunt S. Krozowski, Angela F. de Rodriguez, Mary P. Warden
Publikováno v:
Endocrinology. 149:525-533
Intracellular concentrations of the glucocorticoids cortisol and corticosterone are modulated by the enzymes 11beta-hydroxysteroid dehydrogenase (11beta-HSD) 1 and 2. 11beta-HSD1 is a reduced nicotinamide adenine dinucleotide phosphate (NADPH)-depend
Publikováno v:
Endocrinology. 144:3101-3106
The action of glucocorticoids in target tissues is dependent on the local expression of glucocorticoid receptors and two 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes, 11beta-HSD1 and 11beta-HSD2, which interconvert active and inactive glu
Publikováno v:
Endocrine Research. 29:211-216
The regulation of 11beta-hydroxysteroid dehydrogenase type II (11betaHSD2) expression at the level of specific mRNA and 11betaHSD2 protein was investigated in primary culture of renal epithelial cells of the rat. It has been shown that treatment of t
Autor:
Zygmunt S. Krozowski, Jean-Daniel Sraer, Toshio Kawano, Akihiko Kudo, Kunimasa Yan, Hayato Kawakami, Saeko Kataoka, Tomoatsu Mune, Eiji Higashihara, Hiroshi Hirano, Hirotoshi Tanaka, Françoise Delarue
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 87:877-882
Our previous study demonstrated that the GR is expressed in the human kidney glomerulus. The function of the GR of glomerular cells might be affected by the concentration of intracellular glucocorticoids, which is modulated by 11beta-hydroxysteroid d
Autor:
Zygmunt S. Krozowski, Kaori Koyama
Publikováno v:
Molecular and Cellular Endocrinology. 183:165-170
An important determinant of the potency of steroid hormones is the presence of activating and inactivating enzymes in target cells. The 11 beta-hydroxysteroid dehydrogenase type 1 and type 2 enzymes (11 beta HSD1 and 11 beta HSD2) modulate glucocorti
Autor:
Nobuo Hiwatashi, Junji Takeyama, Yasunari Muramatu, Takayoshi Toyota, Chika Kaneko, Gen Hirasawa, Zygmunt S. Krozowski, Hironobu Sasano, Takashi Suzuki, Hiroshi Nagura, Andrew D. Darnel, Kouhei Fukushima
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:1306-1309
In mineralocorticoid target organs, 11beta-hydroxysteroid dehydrogenase type II (11beta-HSD2) confers specificity on the mineralocorticoid receptor (MR) by converting biologically active glucocorticoids to inactive metabolites. Placental 11beta-HSD2
Autor:
Zygmunt S. Krozowski, Tim J Cole, Meryl J. Fullerton, Hayley J. Harris, Nicola M. Solomon, Robin E. Smith, Isabelle Hoong
Publikováno v:
Molecular and Cellular Endocrinology. 154:29-36
We have investigated hepatic expression and glucocorticoid regulation of the corticosteroid-binding globulin (CBG) gene in mice lacking a functional glucocorticoid receptor (GR). GR −/− mice show impaired negative feedback in the hypothalamic–p
Autor:
Zygmunt S. Krozowski
Publikováno v:
Molecular and Cellular Endocrinology. 151:121-127
The 11beta-hydroxysteroid dehydrogenase enzymes (11beta-HSD) interconvert cortisol and cortisone in man, and corticosterone and 11-dehydrocorticosterone in rodents. Two distantly related congeners have been isolated and conserved domains identified b
Autor:
Hironobu Sasano, Robin E. Smith, K X Z Li, Zygmunt S. Krozowski, Tim J Cole, V.R. Obeyesekere, C Coulter, Karen E. Sheppard, K Koyama, Alicia N Stein-Oakley
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 69:391-401
Local tissue concentrations of glucocorticoids are modulated by the enzyme 11 β -hydroxysteroid dehydrogenase which interconverts cortisol and the inactive glucocorticoid cortisone in man, and corticosterone and 11-dehydrocorticosterone in rodents.