Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Zygmunt S Derewenda"'
Autor:
Darkhan Utepbergenov, Paulina M Hennig, Urszula Derewenda, Mykhaylo V Artamonov, Avril V Somlyo, Zygmunt S Derewenda
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164343 (2016)
Ribosomal S6 kinases (RSK) play important roles in cell signaling through the mitogen-activated protein kinase (MAPK) pathway. Each of the four RSK isoforms (RSK1-4) is a single polypeptide chain containing two kinase domains connected by a linker se
Externí odkaz:
https://doaj.org/article/d40be82a84454e1082d3881bafeba8be
Autor:
Mykhaylo Artamonov, Ko Momotani, Darkhan Utepbergenov, Aaron Franke, Alexander Khromov, Zygmunt S Derewenda, Avril V Somlyo
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58703 (2013)
In the canonical model of smooth muscle (SM) contraction, the contractile force is generated by phosphorylation of the myosin regulatory light chain (RLC20) by the myosin light chain kinase (MLCK). Moreover, phosphorylation of the myosin targeting su
Externí odkaz:
https://doaj.org/article/53ca93556db540b2b84354b9dc296335
Autor:
Jaspreet Kalra, Mykhaylo Artamonov, Hua Wang, Aaron Franke, Zaneta Markowska, Li Jin, Zygmunt S. Derewenda, Ramon J. Ayon, Avril Somlyo
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC20) is a critical switch leading to SM contraction. The canonical view held that only the short isoform of myosin light chain kinase (MLCK1) catalyzed this reaction
Externí odkaz:
https://doaj.org/article/cfd5b73566534942a20862c48cbd93d9
Autor:
Zygmunt S. Derewenda
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:1469-1473
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fce83e3a4865d91ba9d0f548d3e203c
https://doi.org/10.1107/s2059798322010658
https://doi.org/10.1107/s2059798322010658
Autor:
Jaspreet Kalra, Mykhaylo Artamonov, Hua Wang, Aaron Franke, Zaneta Markowska, Li Jin, Zygmunt S. Derewenda, Ramon Ayon, Avril Somlyo
Publikováno v:
bioRxiv
BackgroundPhosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC20) is a critical switch leading to contraction or cell migration. The canonical view held that the only kinase catalyzing this reaction is the short isoform of myosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fca8439294de7db21210c1ae4517b4
https://europepmc.org/articles/PMC10245941/
https://europepmc.org/articles/PMC10245941/
Autor:
Paweł Ł. Janczyk, Eliza Żyłkiewicz, Henry De Hoyos, Thomas West, Daniel R. Matson, Won-Chan Choi, Heather M. Raimer Young, Zygmunt S. Derewenda, P. Todd Stukenberg
Publikováno v:
Molecular Biology of the Cell. 34
Dynein inactivates the spindle assembly checkpoint (SAC) by transporting checkpoint proteins away from kinetochores toward spindle poles in a process known as "stripping." We find that inhibition of Aurora A kinase, which is localized to spindle pole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f47bfa91ecbdfc006b52a821be925c
https://doi.org/10.1091/mbc.e21-09-0438
https://doi.org/10.1091/mbc.e21-09-0438
Autor:
Zygmunt S. Derewenda
Publikováno v:
Acta crystallographica. Section A, Foundations and advances. 77(Pt 5)
The bent structure of the water molecule, and its hydrogen-bonding properties, arguably rank among the most impactful discoveries in the history of chemistry. Although the fact that the H—O—H angle must deviate from linearity was inferred early i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d95dec606b66c80b45f111e9502ca40
https://pubmed.ncbi.nlm.nih.gov/34473092
https://pubmed.ncbi.nlm.nih.gov/34473092
Publikováno v:
IUBMB Life
C—H· · ·O hydrogen bonds constitute a unique class of cohesive interactions. Their properties are similar to those of canonical H-bonds, although their energy is significantly lower, typically in the 0.5–2.5 kcal/mol range. Polarised C—H gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c48f08dde88de4bb5995459d720627
https://europepmc.org/articles/PMC7641297/
https://europepmc.org/articles/PMC7641297/
Autor:
Malwina Radwanska, Zygmunt S. Derewenda, Daniel A. Engel, Urszula Derewenda, Tsuyoshi Miyake, Mateusz Jaskolowski, Elena K. Davydova, Anthony A. Kossiakoff
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:681-689
The vast majority of platforms for the detection of viral or bacterial antigens rely on immunoassays, typically ELISA or sandwich ELISA, that are contingent on the availability of suitable monoclonal antibodies (mAbs). This is a major bottleneck, sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23560d82b1c94475e4cf9adf014c5c8c
https://doi.org/10.1107/s2059798318007878
https://doi.org/10.1107/s2059798318007878
Autor:
Zygmunt S. Derewenda, Malgorzata Bukrejewska, Malwina Radwanska, Urszula Derewenda, Daniel A. Engel
Publikováno v:
Acta Crystallographica Section D Structural Biology. 73:767-774
Two nonstructural proteins encoded byZika virusstrain MR766 RNA, a methyltransferase and a helicase, were crystallized and their structures were solved and refined at 2.10 and 2.01 Å resolution, respectively. The NS5 methyltransferase contains a bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19296b13bad5555b6e9db3948f171276
https://doi.org/10.1107/s2059798317010737
https://doi.org/10.1107/s2059798317010737