Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (vol 53, pg 1636, 2021)

Autor: van Rheenen, W, van der Spek, RAA, Bakker, MK, van Vugt, JJFA, Hop, PJ, Zwamborn, RAJ, de Klein, N, Westra, HJ, Bakker, OB, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, AM, Gawor, K, Westeneng, HJ, Tazelaar, GHP, van Eijk, KR, Kooyman, M, Byrne, RP, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, BN, Gromicho, M, Chandran, S, Pal, S, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Sendtner, M, Meyer, T, Basak, N, van der Kooi, AJ, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, RH, Bell, S, Vourc'h, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Pardina, JMS, Assialioui, A, Rojas-Garcia, R, Dion, PA, Ross, JP, Ludolph, AC, Weishaupt, JH, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, CAM, Saker-Delye, S, Wood, NW, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, DC, Olsen, CM, Uitterlinden, AG, Hofman, A, Rietschel, M, Cichon, S, Nothen, MM, Amouyel, P, Comi, G, Riva, N, Lunetta, C, Gerardi, F, Cotelli, MS, Rinaldi, F, Chiveri, L, Guaita, MC, Perrone, P, Diamanti, L, Ferrarese, C, Tremolizzo, L, Delodovici, ML, Bono, G, Manera, U, Vasta, R, Bombaci, A, Casale, F, Fuda, G, Salamone, P, Iazzolino, B, Peotta, L, Cugnasco, P, De Marco, G, Torrieri, MC, Palumbo, F, Gallone, S, Barberis, M, Sbaiz, L, Gentile, S, Mauro, A, De Marchi, F, D'Alfonso, S, Bertolotto, A, Gionco, M, Leotta, D, Odddenino, E, Imperiale, D, Cavallo, R, Pignatta, P, De Mattei, M, Geda, C, Papurello, DM, Gusmaroli, G, Comi, C, Labate, C, Ruiz, L, Ferrandi, D, Rota, E, Aguggia, M, Di Vito, N, Meineri, P, Ghiglione, P, Launaro, N, Dotta, M, Di Sapio, A, Giardini, G, Tiloca, C, Peverelli, S, Taroni, F, Pensato, V, Castellotti, B, Comi, GP, Del Bo, R, Ceroni, M, Gagliardi, S, Corrado, L, Mazzini, L, Raggi, F, Simoncini, C, Lo Gerfo, A, Inghilleri, M, Ferlini, A, Simone, IL, Passarella, B, Guerra, V, Zoccolella, S, Nozzoli, C, Mundi, C, Leone, M, Zarrelli, M, Tamma, F, Valluzzi, F, Calabrese, G, Boero, G, Rini, A, Traynor, BJ, Singleton, AB, Neto, MM, Cauchi, RJ, Ophoff, RA, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, VM, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, OW, Steinbach, R, Hubner, CA, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, IP, Kiernan, MC, Benyamin, B, Henderson, RD, Furlong, S, Mathers, S, McCombe, PA, Needham, M, Ngo, ST, Nicholson, GA, Pamphlett, R, Rowe, DB, Steyn, FJ, Williams, KL, Mather, KA, Sachdev, PS, Henders, AK, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, GA, Silani, V, Curtis, CJ, Breen, G, Glass, JD, Brown, RH, Landers, JE, Shaw, CE, Andersen, PM, Groen, EJN, van Es, MA, Pasterkamp, RJ, Fan, DS, Garton, FC, McRae, AF, Smith, GD, Gaunt, TR, Eberle, MA, Mill, J, McLaughlin, RL, Hardiman, O, Kenna, KP, Wray, NR, Tsai, EL, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, LH, Veldink, JH, SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium

Publikováno v: NATURE GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::14d0bed056ea6e9b6c5550b9e67e8ce3
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8163

Genetic variability in sporadic amyotrophic lateral sclerosis.

Autor: Van Daele SH; Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, and Leuven Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium.; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, 3000 Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, 3000 Leuven, Belgium.; Department of Human genetics, University Hospitals Leuven, 3000 Leuven, Belgium., Moisse M; Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, and Leuven Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium.; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, 3000 Leuven, Belgium., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., van der Spek R; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Van Eijk K; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Kenna K; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Corcia P; Centre SLA, CHRU de Tours, 37044 Tours, France.; UMR 1253, iBrain, Université de Tours, Inserm, 37032 Tours, France., Vourc'h P; UMR 1253, iBrain, Université de Tours, Inserm, 37032 Tours, France., Couratier P; Centre SLA, CHU Limoges, 87042 Limoges, France., Hardiman O; Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin D02 PN40, Republic of Ireland., McLaughin R; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin D02 PN40, Republic of Ireland., Gotkine M; The Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, 91120 Jerusalem, Israel., Drory V; Department of Neurology, Tel-Aviv Sourasky Medical Centre, 64239 Tel Aviv, Israel., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20149 Milano, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, 20122 Milan, Italy., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20149 Milano, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, 20122 Milan, Italy., Ratti A; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20149 Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20133 Milano, Italy., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal., Mora Pardina JS; ALS Unit, Hospital University San Rafael, 28016 Madrid, Spain., Povedano M; Servei de Neurologia, HUB-IDIBELL, 08908 Barcelona, Spain., Andersen PM; Department of Clinical Science, Neurosciences, Umeå University, 901 87 Umeå, Sweden., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland., Başak NA; Koç University, School of Medicine, KUTTAM-NDAL, 34010 Istanbul, Turkey., Shaw C; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London SE5 9RT, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK., Morrison KE; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7BL, UK., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA., van Es MA; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London SE5 9RT, UK., Veldink J; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands., Van Damme P; Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, and Leuven Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium.; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, 3000 Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, 3000 Leuven, Belgium.

Publikováno v: Brain : a journal of neurology [Brain] 2023 Sep 01; Vol. 146 (9), pp. 3760-3769.

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.

Autor: van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. w.vanrheenen-2@umcutrecht.nl., van der Spek RAA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bakker MK; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hop PJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Klein N; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Westra HJ; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Bakker OB; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Deelen P; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Shireby G; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Hannon E; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Moisse M; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., Baird D; Translational Biology, Biogen, Boston, MA, USA.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK., Restuadi R; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Dolzhenko E; Illumina, San Diego, CA, USA., Dekker AM; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Gawor K; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Westeneng HJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Tazelaar GHP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Eijk KR; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kooyman M; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Byrne RP; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doherty M; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Heverin M; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Al Khleifat A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Iacoangeli A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK., Shatunov A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ticozzi N; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Smith BN; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gromicho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Chandran S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Pal S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Morrison KE; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK., Orrell RW; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Sendtner M; Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany., Meyer T; Charité University Hospital, Humboldt University, Berlin, Germany., Başak N; Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey., van der Kooi AJ; Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands., Ratti A; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy., Fogh I; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy., Lauria G; 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', MIlan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Corti S; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy.; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Cereda C; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., Sproviero D; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., D'Alfonso S; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy., Sorarù G; Department of Neurosciences, University of Padova, Padova, Italy., Siciliano G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Filosto M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Padovani A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Brunetti M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Canosa A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Grassano M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Beghi E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Pupillo E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Logroscino G; Department of Clinical Research in Neurology, University of Bari at 'Pia Fondazione Card G. 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Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bell S; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Vourc'h P; Service de Biochimie et Biologie Moléculaire, CHU de Tours, Tours, France.; UMR 1253, Université de Tours, Inserm, Tours, France., Corcia P; UMR 1253, Université de Tours, Inserm, Tours, France.; Centre de référence sur la SLA, CHU de Tours, Tours, France., Couratier P; Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.; UMR 1094, Université de Limoges, Inserm, Limoges, France., Millecamps S; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France., Meininger V; Hôpital des Peupliers, Ramsay Générale de Santé, Paris, France., Salachas F; 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Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Braun A; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Kraft J; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Whiteman DC; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Olsen CM; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Uitterlinden AG; Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Hofman A; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Rietschel M; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.; Central Institute of Mental Health, Mannheim, Germany., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany.; Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Juelich, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany., Amouyel P; INSERM UMR1167-RID-AGE LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, Centre Hospitalier of the University of Lille, Institut Pasteur de Lille, Lille, France., Traynor BJ; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA., Mitne Neto M; Universidade de São Paulo, São Paulo, Brazil., Cauchi RJ; Centre for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta., Ophoff RA; University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Wiedau-Pazos M; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Lomen-Hoerth C; Department of Neurology, University of California, San Francisco, CA, USA., van Deerlin VM; Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Grosskreutz J; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.; Precision Neurology Unit, Department of Neurology, University Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany., Roediger A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Gaur N; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Jörk A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Barthel T; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Theele E; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Ilse B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Stubendorff B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Witte OW; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Steinbach R; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Hübner CA; Institute of Human Genetics, Jena University Hospital, Jena, Germany., Graff C; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Brylev L; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Fominykh V; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Demeshonok V; ALS-Care Center, 'GAOORDI', Medical Clinic of the St. Petersburg, St. Petersburg, Russia., Ataulina A; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia., Rogelj B; Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.; Biomedical Research Institute BRIS, Ljubljana, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Koritnik B; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Zidar J; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Ravnik-Glavač M; Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Glavač D; Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Stević Z; Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia., Drory V; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Povedano M; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Blair IP; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Benyamin B; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Australian Centre for Precision Health and Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia., Henderson RD; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Furlong S; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, Victoria, Australia., McCombe PA; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Needham M; Fiona Stanley Hospital, Perth, Western Australia, Australia.; Notre Dame University, Fremantle, Western Australia, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Ngo ST; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Nicholson GA; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.; Northcott Neuroscience Laboratory, ANZAC Research Institute, Concord, New South Wales, Australia.; Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Steyn FJ; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; The School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Williams KL; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia Institute, Randwick, New South Wales, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, the Prince of Wales Hospital, UNSW, Randwick, New South Wales, Australia., Henders AK; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Wallace L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Pinto S; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Petri S; Department of Neurology, Hannover Medical School, Hannover, Germany., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Silani V; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Curtis CJ; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Breen G; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA, USA., Brown RH Jr; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Shaw CE; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Andersen PM; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Groen EJN; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Es MA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fan D; Department of Neurology, Third Hospital, Peking University, Beijing, China., Garton FC; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Eberle MA; Illumina, San Diego, CA, USA., Mill J; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., McLaughlin RL; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Kenna KP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Tsai E; Translational Biology, Biogen, Boston, MA, USA., Runz H; Translational Biology, Biogen, Boston, MA, USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; King's College Hospital, London, UK., Van Damme P; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.veldink@umcutrecht.nl.

Publikováno v: Nature genetics [Nat Genet] 2022 Mar; Vol. 54 (3), pp. 361.

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis.

Autor: Al Khleifat A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Iacoangeli A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Bowles H; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Moisse M; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology; VIB Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van der Spek RAA; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Shatunov A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Topp S; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Byrne R; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Gellera C; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano and Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milano, Italy., López V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano and Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milano, Italy., Jones AR; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Opie-Martin S; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Vural A; Koc University, School of Medicine, Translational Medicine Research Center- NDAL, Istanbul, Turkey., Campos Y; Mitochondrial pathology Unit, Instituto de Salud Carlos III, Madrid, Spain., van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Kenna B; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Van Eijk KR; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Kenna K; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland., Smith B; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Fogh I; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano and Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milano, Italy., Morrison KE; Faculty of Medicine, Health and Life Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK., Dobson R; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Institute of Health Informatics, University College London, London, UK., van Es MA; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., McLaughlin RL; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Vourc'h P; Centre SLA, CHRU de Tours, Tours, France., Chio A; Rita Levi Montalcini, Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Azienda Ospedaliera Citta della Salute e della Scienza, Torino, Italy., Corcia P; Centre SLA, CHRU de Tours, Tours, France.; Federation des Centres SLA Tours and Limoges, LITORALS, Tours, France., de Carvalho M; Physiology Institute, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal., Gotkine M; Hadassah University Hospital, Jerusalem, Israel., Panades MP; Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain., Mora JS; Hospital San Rafael, Madrid, Spain., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Glass JD; Department of Neurology, Center for Neurodegenerative Diseases, Emory University, Atlanta, GA, USA., Shaw CE; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK.; King's College Hospital, Denmark Hill, London, UK., Basak N; Koc University, School of Medicine, Translational Medicine Research Center- NDAL, Istanbul, Turkey., Hardiman O; Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Republic of Ireland.; Department of Neurology, Beaumont Hospital, Dublin, Republic of Ireland., Robberecht W; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology; VIB Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.; Neurology Department, University Hospitals Leuven, Leuven, Belgium., Van Damme P; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology; VIB Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.; Neurology Department, University Hospitals Leuven, Leuven, Belgium., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Al-Chalabi A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, De Crespigny Park, London, UK. ammar.al-chalabi@kcl.ac.uk.; King's College Hospital, Denmark Hill, London, UK. ammar.al-chalabi@kcl.ac.uk.

Publikováno v: NPJ genomic medicine [NPJ Genom Med] 2022 Jan 28; Vol. 7 (1), pp. 8. Date of Electronic Publication: 2022 Jan 28.

The Effect of SMN Gene Dosage on ALS Risk and Disease Severity.

Autor: Moisse M; Departments of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain and Disease Research, Leuven, Belgium., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van Vugt J; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van der Spek R; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Kenna B; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Van Eijk K; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Kenna K; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Corcia P; Centre SLA, CHRU de Tours, Tours, France.; UMR 1253, iBrain, Université de Tours, Inserm, Tours, France., Couratier P; Centre SLA, CHRU de Tours, Tours, France., Vourc'h P; UMR 1253, iBrain, Université de Tours, Inserm, Tours, France., Hardiman O; Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Republic of Ireland., McLaughin R; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Republic of Ireland., Gotkine M; The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Drory V; Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel Aviv, Israel., Ticozzi N; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Silani V; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Mora Pardina JS; ALS Unit, Hospital San Rafael, Madrid, Spain., Povedano M; Servei de Neurologia, HUB-IDIBELL, Barcelona, Spain., Andersen PM; Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden., Weber M; Neuromuscular Diseases Unit/ALS Clinic, St. Gallen, Switzerland., Başak NA; Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey., Chen X; Illumina Inc., San Diego, CA., Eberle MA; Illumina Inc., San Diego, CA., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Shaw C; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Morrison KE; School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA., Robberecht W; Departments of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., van Es M; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van den Berg L; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Veldink J; Department of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Van Damme P; Departments of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain and Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

Publikováno v: Annals of neurology [Ann Neurol] 2021 Apr; Vol. 89 (4), pp. 686-697. Date of Electronic Publication: 2021 Jan 15.