PHYSICO-CHEMICAL VERIFICATION OF THE APPLICATION OF THE CYTOSTATIC IMMOBILAZED FORM IN OVARIAN CANCER THERAPY

Autor: Kuznetsov Vyacheslav A., Lavlinskaya Maria S., Sorokin Andrey V., Bykovskii Dmitrii V., Khvostovoy Vladimir V., Frolova Oksana G., Zvyagin Ivan N.

Publikováno v: Конденсированные среды и межфазные границы, Vol 19, Iss 4, Pp 523-528 (2017)

The aim of the research is to study the interaction between “Linteks-Mesogel” and paclitaxel, antitumor pharmaceutical substances. The object of the research is “Linteks-Mesogel”, a concentrated water solution of sodium salt of carboxymethyl

Externí odkaz: https://doaj.org/article/69bdc34937164b4896f432c197aa5643

Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires.

Autor: Pavlova AV; Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Zvyagin IV; Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Dmitriy Rogachev National Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Shugay M; Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Apr 03; Vol. 15, pp. 1321603. Date of Electronic Publication: 2024 Apr 03 (Print Publication: 2024).

Targeted depletion of TRBV9 ⁺ T cells as immunotherapy in a patient with ankylosing spondylitis.

Autor: Britanova OV; Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Lupyr KR; Pirogov Russian National Research Medical University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Moscow, Russia., Staroverov DB; Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Shagina IA; Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Aleksandrov AA; BIOCAD, St. Petersburg, Russia., Ustyugov YY; BIOCAD, St. Petersburg, Russia., Somov DV; Pirogov Russian National Research Medical University, Moscow, Russia., Klimenko A; Pirogov Russian National Research Medical University, Moscow, Russia., Shostak NA; Pirogov Russian National Research Medical University, Moscow, Russia., Zvyagin IV; Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Stepanov AV; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Merzlyak EM; Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Davydov AN; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.; MiLaboratories Inc., Sunnyvale, CA, USA., Izraelson M; MiLaboratories Inc., Sunnyvale, CA, USA., Egorov ES; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany., Bogdanova EA; Pirogov Russian National Research Medical University, Moscow, Russia., Vladimirova AK; BIOCAD, St. Petersburg, Russia., Iakovlev PA; BIOCAD, St. Petersburg, Russia., Fedorenko DA; Department of Hematology and Chemotherapy, Pirogov National Medical and Surgical Center, Moscow, Russia., Ivanov RA; BIOCAD, St. Petersburg, Russia., Skvortsova VI; Pirogov Russian National Research Medical University, Moscow, Russia.; Federal Medical Biological Agency, Moscow, Russia., Lukyanov S; Pirogov Russian National Research Medical University, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Chudakov DM; Pirogov Russian National Research Medical University, Moscow, Russia. chudakovdm@gmail.com.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. chudakovdm@gmail.com.; Central European Institute of Technology, Masaryk University, Brno, Czech Republic. chudakovdm@gmail.com.; Abu Dhabi Stem Cell Center, Al Muntazah, United Arab Emirates. chudakovdm@gmail.com.

Publikováno v: Nature medicine [Nat Med] 2023 Nov; Vol. 29 (11), pp. 2731-2736. Date of Electronic Publication: 2023 Oct 23.

HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes.

Autor: Karnaukhov V; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia., Paes W; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Woodhouse IB; Medical Research Council (MRC) Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.; Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) Centre for Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom., Partridge T; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Nicastri A; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Brackenridge S; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Shcherbinin D; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia., Chudakov DM; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia., Zvyagin IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia., Ternette N; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Koohy H; Medical Research Council (MRC) Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.; Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) Centre for Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom., Borrow P; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Shugay M; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Dec 20; Vol. 13, pp. 1067463. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022).

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.

Autor: Yang X; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Garner LI; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Zvyagin IV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russian Federation.; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation., Paley MA; Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Komech EA; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russian Federation.; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation., Jude KM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Zhao X; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Fernandes RA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Hassman LM; Department of Ophthalmology, Washington University School of Medicine, St Louis, MO, USA., Paley GL; Department of Ophthalmology, Washington University School of Medicine, St Louis, MO, USA., Savvides CS; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Brackenridge S; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Quastel MN; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Chudakov DM; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russian Federation.; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation., Bowness P; Nuffield Department of Orthopaedics Rheumatology and Muscuoskeletal Science (NDORMS), Botnar Research Center, University of Oxford, Oxford, UK., Yokoyama WM; Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. yokoyama@dom.wustl.edu.; Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA. yokoyama@dom.wustl.edu., McMichael AJ; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK. andrew.mcmichael@ndm.ox.ac.uk.; Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK. andrew.mcmichael@ndm.ox.ac.uk., Gillespie GM; NDM Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK. geraldine.gillespie@ndm.ox.ac.uk.; Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK. geraldine.gillespie@ndm.ox.ac.uk., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.

Publikováno v: Nature [Nature] 2022 Dec; Vol. 612 (7941), pp. 771-777. Date of Electronic Publication: 2022 Dec 07.