Targeting SARS-CoV-2 Main Protease (MPro) with Kinase Inhibitors: A Promising Approach for Discovering Antiviral and Anti-inflammatory Molecules against SARS-CoV-2.

Autor: Anton DB; Biotechnology Graduate Program, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil., Galvez Bulhões Pedreira J; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen 72076, Germany., Zvirtes ML; Department of Medicine, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil., Laufer SA; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen 72076, Germany., Ducati RG; Biotechnology Graduate Program, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil.; Department of Medicine, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil., Goettert M; Biotechnology Graduate Program, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil.; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen 72076, Germany.; Medical Science Graduate Program, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil., Saraiva Macedo Timmers LF; Biotechnology Graduate Program, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil.; Department of Medicine, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil.; Medical Science Graduate Program, Universidade do Vale do Taquari (Univates), Lajeado CEP 95914-014, Brazil.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2023 Jul 10; Vol. 63 (13), pp. 4138-4146. Date of Electronic Publication: 2023 Jun 17.