Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Zvia Agur"'
Autor:
Yuri Kogan, Ari Robinson, Edward Itelman, Yeonatan Bar-Nur, Daniel Jorge Jakobson, Gad Segal, Zvia Agur
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Our study was aimed at developing and validating a new approach, embodied in a machine learning-based model, for sequentially monitoring hospitalized COVID-19 patients and directing professional attention to patients whose deterioration is i
Externí odkaz:
https://doaj.org/article/9c24c766910e45fabd5dd76acd9a3a40
Autor:
Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem, Zvia Agur
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background At present, immune checkpoint inhibitors, such as pembrolizumab, are widely used in the therapy of advanced non-resectable melanoma, as they induce more durable responses than other available treatments. However, the overall respo
Externí odkaz:
https://doaj.org/article/b755296c408f4d62bce273d786ad6e82
Autor:
Avi Gillis, Michael Beil, Karin Halevi-Tobias, Peter Vernon van Heerden, Sigal Sviri, Zvia Agur
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study was to identify the mai
Externí odkaz:
https://doaj.org/article/df32d085bed4470e9c7b2d80ec5ddb9a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Background: Recently, there has been a growing interest in applying immune checkpoint blockers (ICBs), so far used to treat cancer, to patients with bacterial sepsis. We aimed to develop a method for predicting the personal benefit of potential treat
Externí odkaz:
https://doaj.org/article/3682a636975f488a85a23bada3120a8b
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179888 (2017)
Despite considerable investigational efforts, no method to overcome the pathogenesis caused by loss of function (LoF) mutations in tumor suppressor genes has been successfully translated to the clinic. The most frequent LoF mutation in human cancers
Externí odkaz:
https://doaj.org/article/cafa3ac485bd4a708bf99537253e8b6f
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 9, p e1002206 (2011)
Interleukin (IL)-21 is an attractive antitumor agent with potent immunomodulatory functions. Yet thus far, the cytokine has yielded only partial responses in solid cancer patients, and conditions for beneficial IL-21 immunotherapy remain elusive. The
Externí odkaz:
https://doaj.org/article/43b47d5569ce41b1879fd0a0b5b105fc
Autor:
Zvia Agur, Oleg U Kirnasovsky, Genadiy Vasserman, Lilach Tencer-Hershkowicz, Yuri Kogan, Hannah Harrison, Rebecca Lamb, Robert B Clarke
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24225 (2011)
BackgroundModulation of cellular signaling pathways can change the replication/differentiation balance in cancer stem cells (CSCs), thus affecting tumor growth and recurrence. Analysis of a simple, experimentally verified, mathematical model suggests
Externí odkaz:
https://doaj.org/article/357ff7d520244ea3a0cb1453ce4dd75a
Autor:
Eva Jager, Vincent H J van der Velden, Jeroen G te Marvelde, Roland B Walter, Zvia Agur, Vladimir Vainstein
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24265 (2011)
Gemtuzumab ozogamicin (GO) is a chemotherapy-conjugated anti-CD33 monoclonal antibody effective in some patients with acute myeloid leukemia (AML). The optimal treatment schedule and optimal timing of GO administration relative to other agents remain
Externí odkaz:
https://doaj.org/article/ad03ae95569d4840b52761033db784ed
Autor:
Natalie Kronik, Yuri Kogan, Moran Elishmereni, Karin Halevi-Tobias, Stanimir Vuk-Pavlović, Zvia Agur
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15482 (2010)
Therapeutic vaccination against disseminated prostate cancer (PCa) is partially effective in some PCa patients. We hypothesized that the efficacy of treatment will be enhanced by individualized vaccination regimens tailored by simple mathematical mod
Externí odkaz:
https://doaj.org/article/952b59b0344e4d87863189ace83d4920
PDF file - 201K, The contents of the document: 1. Model equations for the vaccine and the maturing DCs 2. Formal description of the algorithm for in-treatment therapy personalization 3. Success-of-validation criteria 4. Model comparison grade and par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601a233934357fc933ae2a19eb2fb6c5
https://doi.org/10.1158/0008-5472.22396031
https://doi.org/10.1158/0008-5472.22396031