Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model

Autor: Sophie Quick, Tessa V. Procter, Jonathan Moss, Luise Seeker, Marc Walton, Angus Lawson, Serena Baker, Anna Beletski, Daniela Jaime Garcia, Mehreen Mohammad, William Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A. Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O. Bernabeu, Joanna M. Wardlaw, Anna Williams

Publikováno v: Quick, S, Procter, T, Moss, J, Seeker, L, Walton, M, Lawson, A, Baker, S, Beletski, A, Jaime Garcia, D, Mohammad, M, Mungall, W, Onishi, A, Tobola, Z, Stringer, M, Jansen, M, Vallatos, A, Giarratano, Y, Bernabeu, M O, Wardlaw, J M & Williams, A C 2022, ' Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model ', Acta Neuropathologica, vol. 144, no. 2, pp. 283-303 . https://doi.org/10.1007/s00401-022-02441-4

Cerebral small vessel disease (SVD) is the leading cause of vascular dementia, causes a quarter of strokes, and worsens stroke outcomes. The disease is characterised by patchy cerebral small vessel and white matter pathology, but the underlying mecha

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https://www.pure.ed.ac.uk/ws/files/280682874/ANEU_D_22_00297_R1_1_.pdf