Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zuzanna Maniecka"'
Autor:
Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie Jambeau, Larissa A. B. Gilhespy, Florent Laferriere, Zuzanna Maniecka, Andreas Plückthun, Peer Mittl, Paolo Paganetti, Frédéric H. T. Allain, Magdalini Polymenidou
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TDP-43 aggregation is observed in amyotrophic lateral sclerosis. Here the authors combine X-ray crystallography, nuclear magnetic resonance and electron microscopy studies and show that physiological oligomerization of TDP-43 is mediated through its
Externí odkaz:
https://doaj.org/article/19fe9db6d453476b99cb7c03271c33ca
Autor:
Monika I Banko, Marek K Krzyzanowski, Paulina Turcza, Zuzanna Maniecka, Marta Kulis, Piotr Kozlowski
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e74885 (2013)
ERH is a small, highly evolutionarily conserved nuclear protein of unknown function. Its three-dimensional structure is absolutely unique and it can form a homodimer through a β sheet surface. ERH has been shown to interact, among others, with PDIP4
Externí odkaz:
https://doaj.org/article/c938a38067844c67806b26b6141b2763
Autor:
Melanie, Jambeau, Kevin D, Meyer, Marian, Hruska-Plochan, Ricardos, Tabet, Chao-Zong, Lee, Ananya, Ray-Soni, Corey, Aguilar, Kitty, Savage, Nibha, Mishra, Nicole, Cavegn, Petra, Borter, Chun-Chia, Lin, Karen R, Jansen-West, Jie, Jiang, Fernande, Freyermuth, Nan, Li, Pierre, De Rossi, Manuela, Pérez-Berlanga, Xin, Jiang, Lilian M, Daughrity, João, Pereira, Sarav, Narayanan, Yuanzheng, Gu, Shekhar, Dhokai, Isin, Dalkilic-Liddle, Zuzanna, Maniecka, Julien, Weber, Michael, Workman, Melissa, McAlonis-Downes, Eugene, Berezovski, Yong-Jie, Zhang, James, Berry, Brian J, Wainger, Mark W, Kankel, Mia, Rushe, Christoph, Hock, Roger M, Nitsch, Don W, Cleveland, Leonard, Petrucelli, Tania F, Gendron, Fabio, Montrasio, Jan, Grimm, Magdalini, Polymenidou, Clotilde, Lagier-Tourenne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
Hexanucleotide G
Autor:
Christoph Renner, Ulrich Mey, Christoph Driessen, Jeroen S. Goede, Thomas Pabst, Stefanie Hayoz, Thilo Zander, Erika Lerch, Tobias Pabst, Axel Rüfer, Sämi Schär, Gaëlle Rhyner, Urban Novak, Stefan Aebi, Zuzanna Maniecka
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S165
Background Pomalidomide (POM) with dexamethasone (DEX) is approved in patients (pts) with relapsed and refractory (RRMM) myeloma and achieved a progression free survival (PFS) between 4.0 and 4.6 months in two pivotal phase III trials (MM-003 and MM-
Autor:
Sandrine C. Foti, Ulrich Wagner, Florent Laferrière, Paul J. Boersema, Magdalini Polymenidou, Erwan Bezard, Marian Hruska-Plochan, Tammaryn Lashley, Amanda J Lewis, Ashraf Al-Amoudi, Francesca De Giorgi, Yasmine T. Asi, Henning Stahlberg, Larissa A. B. Gilhespy, Zuzanna Maniecka, Eva-Maria Hock, Paola Picotti, Gery Barmettler, Tariq Afroz, Adrian M. Isaacs, John Ravits, François Ichas, Manuela Pérez-Berlanga
Publikováno v:
Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
Nature Neuroscience, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
Nature Neuroscience, Nature Publishing Group, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
Nature Neuroscience, 2019, 22 (1), pp.65-77. ⟨10.1038/s41593-018-0294-y⟩
International audience; Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d65522d507f8f98fb08f2c4a3944e6
https://hal.archives-ouvertes.fr/hal-02492708
https://hal.archives-ouvertes.fr/hal-02492708
Autor:
Zuzanna Maniecka, Nicolas Mach, Miklos Pless, Roland Seiler, Stefanie Aeppli, Martin Spahn, Raeto Strebel, Ulf Petrausch, Sacha I. Rothschild, Mathias Schmid, Martina Schneider, Dominik Berthold, Boris A. Hadaschik, Andreas Erdmann, Richard Cathomas, Stefanie Hayoz, Julian Schardt, Deborah Zihler
Publikováno v:
Journal of Clinical Oncology. 39:430-430
430 Background: The combination of cisplatin-based chemotherapy with immune checkpoint inhibitors is extensively investigated in urothelial carcinoma. Using this combination in the neoadjuvant setting for patients (pts) with MIUC might improve pathol
Autor:
Dorothee Dormann, Stefan Reber, Luc Dupuis, Helena Ederle, Marian Hruska-Plochan, Eva-Maria Hock, Marc-David Ruepp, Florent Laferrière, Zuzanna Maniecka, Lucas Pelkmans, M K Sonu Sahadevan, Tammaryn Lashley, Lauren M. Gittings, Magdalini Polymenidou
Publikováno v:
Cell Reports
Cell Reports, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Cell Reports, Elsevier Inc, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Hock, E-M, Maniecka, Z, Hruska-Plochan, M, Reber, S, Laferrière, F, Sahadevan M K, S, Ederle, H, Gittings, L, Pelkmans, L, Dupuis, L, Lashley, T, Ruepp, M-D, Dormann, D & Polymenidou, M 2018, ' Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function ', Cell Reports, vol. 24, no. 4, pp. 987-1000.e7 . https://doi.org/10.1016/j.celrep.2018.06.094
Cell Reports, 24 (4)
Cell Reports, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Cell Reports, Elsevier Inc, 2018, 24 (4), pp.987-1000.e7. ⟨10.1016/j.celrep.2018.06.094⟩
Hock, E-M, Maniecka, Z, Hruska-Plochan, M, Reber, S, Laferrière, F, Sahadevan M K, S, Ederle, H, Gittings, L, Pelkmans, L, Dupuis, L, Lashley, T, Ruepp, M-D, Dormann, D & Polymenidou, M 2018, ' Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function ', Cell Reports, vol. 24, no. 4, pp. 987-1000.e7 . https://doi.org/10.1016/j.celrep.2018.06.094
Cell Reports, 24 (4)
The primarily nuclear RNA-binding protein FUS (fused in sarcoma) forms pathological cytoplasmic inclusions in a subset of early-onset amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. In response to cellular stress, FUS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26cd76ee2b60a0880af6400794f15f6
https://doi.org/10.1016/j.celrep.2018.06.094
https://doi.org/10.1016/j.celrep.2018.06.094
Autor:
Frédéric H.-T. Allain, Eva-Maria Hock, Zuzanna Maniecka, Paolo Paganetti, Tariq Afroz, Florent Laferrière, Melanie Jambeau, Andreas Plückthun, Larissa A. B. Gilhespy, Peer R. E. Mittl, Patrick Ernst, Chiara Foglieni, Magdalini Polymenidou
Publikováno v:
Nature Communications, 8
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-00062-0⟩
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-00062-0⟩
TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaae6f0f420f5da2d70eec633d093e1
Publikováno v:
Virus Research
Propagation of pathological protein assemblies via a prion-like mechanism has been suggested to drive neurodegenerative diseases, such as Parkinson's and Alzheimer's. Recently, amyotrophic lateral sclerosis (ALS)-linked proteins, such as SOD1, TDP-43