Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells

Autor: Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Floßdorf, Ahmed N. Hegazy, Thomas Höfer, Max Löhning, Kevin Thurley

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid phenotypes

Externí odkaz: https://doaj.org/article/fe87560e0a3d470ead6141bdb22596eb

Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

Autor: Adriaan van der Graaf, Maria M. Zorro, Annique Claringbould, Urmo Võsa, Raúl Aguirre-Gamboa, Chan Li, Joram Mooiweer, Isis Ricaño-Ponce, Zuzanna Borek, Frits Koning, Yvonne Kooy-Winkelaar, Ludvig M. Sollid, Shuo-Wang Qiao, Vinod Kumar, Yang Li, Lude Franke, Sebo Withoff, Cisca Wijmenga, Serena Sanna, Iris Jonkers, BIOS Consortium

Publikováno v: Frontiers in Genetics, Vol 11 (2021)

Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in these loci a

Externí odkaz: https://doaj.org/article/e122b2ecbc904b5f84b6bf409f7973ed

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

Autor: Frits Koning, Yang Li, Joost H.A. Martens, Aarón D. Ramírez-Sánchez, Olivier B. Bakker, Vinod Kumar, Rutger Modderman, Zuzanna Borek, Marie K. Johannesen, Ludvig M. Sollid, Yvonne Kooy-Winkelaar, Filomena Matarese, Knut E.A. Lundin, Iris Jonkers, Niek de Klein, Shuo-Wang Qiao, Cisca Wijmenga, Jeroen van Bergen, Sebo Withoff

Publikováno v: Scientific Reports, 11, 1
Scientific Reports, 11(1):9252, 1-15. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, 11(1). NATURE RESEARCH
Scientific Reports, 11

Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instigating facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f64629d645aa8a255bdaa5b3903393
https://doi.org/10.1038/s41598-021-86612-5

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

Autor: Sebo Withoff, Cisca Wijmenga, Xiaojin Chu, Patrick Deelen, Roy Oelen, Irma Joosten, Olivier B. Bakker, Annique Claringbould, Yang Li, Mihai G. Netea, Jennifer di Tommaso, Iris Jonkers, Vinod Kumar, Morris A. Swertz, Monique G. P. van der Wijst, Maria M. Zorro, Zuzanna Borek, Serena Sanna, Isis Ricaño-Ponce, Dylan H. de Vries, Lude Franke, Hans J. P. M. Koenen, Harm Brugge, Cheng-Jian Xu, Raul Aguirre-Gamboa, Niek de Klein, Urmo Võsa, Leo A. B. Joosten

Publikováno v: BMC bioinformatics
England
Bmc Bioinformatics, 21(1):243. BioMed Central Ltd.
BMC Bioinformatics
BMC Bioinformatics, 21, 1
BMC Bioinformatics, 21
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-23 (2020)

Background Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28c682c53dee8c14d4e424a1a4efe58
https://doi.org/10.1101/548669