Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zuzana Zachar"'
Autor:
Moises O. Guardado Rivas, Shawn D. Stuart, Daniel Thach, Michael Dahan, Robert Shorr, Zuzana Zachar, Paul M. Bingham
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Clinical targeting of the altered metabolism of tumor cells has long been considered an attractive hypothetical approach. However, this strategy has yet to perform well clinically. Metabolic redundancy is among the limitations on effectiveness of man
Externí odkaz:
https://doaj.org/article/05f83f885dc14eafa50acfa0cf917468
Publikováno v:
American Journal of Roentgenology. 209:270-276
OBJECTIVE. In this article, we provide a general overview of how cancer cells subvert critical metabolic pathways to support their growth and unchecked division. Furthermore, we outline how molecular imaging can diagnostically exploit the resulting d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1195cbe3ef7d67f38cc9309347db261
https://doi.org/10.2214/ajr.17.18112
https://doi.org/10.2214/ajr.17.18112
Autor:
Angela Tatiana Alistar, Tamjeed Ahmed, Umit Topaloglu, Wei Zhang, Paul M. Bingham, Clancy J. Clark, Lakmal W. Boteju, Gregory A. Hawkins, Timothy S. Pardee, Keyanoosh Hosseinzadeh, John R. Leyendecker, Amy Cameron, Asela R Boteju, Bonny Morris, Heidi D. Klepin, Boris Pasche, Zuzana Zachar, Riddhishkumar Shah, Guangxu Jin, Ralph B. D'Agostino, Rob Shorr, John J Migliano, Rodwige Desnoyer, Sandrine Crane, Lance D. Miller
Publikováno v:
The Lancet Oncology. 18:770-778
Summary Background Pancreatic cancer statistics are dismal, with a 5-year survival of less than 10%, and more than 50% of patients presenting with metastatic disease. Metabolic reprogramming is an emerging hallmark of pancreatic adenocarcinoma. CPI-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3542a6427cb7c92f969528d2a13694be
https://doi.org/10.1016/s1470-2045(17)30314-5
https://doi.org/10.1016/s1470-2045(17)30314-5
Publikováno v:
Expert Review of Clinical Pharmacology. 7:837-846
The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1454f10019d4919dd969b1a6d9d165b2
https://doi.org/10.1586/17512433.2014.966816
https://doi.org/10.1586/17512433.2014.966816
Autor:
Timothy S. Pardee, Akiva Mintz, Paul M. Bingham, Kiran Kumar Solingapuram Sai, Anirudh Sattiraju, Michael S. Dahan, Zuzana Zachar, Robert Shorr
Publikováno v:
Cancer Research. 78:4861-4861
CPI-613 is a novel inhibitor of mitochondrial metabolism that has recently shown promise in early stage clinical trials for pancreatic cancer, lymphoma, and leukemia. It is a lipoate analogue that selectively inhibits pyruvate dehydrogenase (PDH) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db68cac07467f4a229c888016aaa2dbd
https://doi.org/10.1158/1538-7445.am2018-4861
https://doi.org/10.1158/1538-7445.am2018-4861
Autor:
Kiran Kumar Solingapuram Sai, Paul M. Bingham, Boris Pasche, Zuzana Zachar, Anirudh Sattiraju, Frankis Almaguel, Stephanie Rideout, Minghui Wang, Moises Guardado, Michael S. Dahan, Shawn D. Stuart, Akiva Mintz
Publikováno v:
Cancer Research. 77:2867-2867
CPI-613 is a lipoate analogue that has been shown to inhibit the pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KGDH) complexes selectively in tumor cells (reviewed in Exp.Rev.Clin.Pharma. 7, 837). These two enzymes control the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::046c85b6d65c06ba307614ea746ef549
https://doi.org/10.1158/1538-7445.am2017-2867
https://doi.org/10.1158/1538-7445.am2017-2867
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9781461495444
The last decade has witnessed the accumulation of a formidable body of evidence that matter/energy metabolism in tumor cells is quite distinct from that of most normal cells. At the same time, diverse data indicate that the redox metabolism (includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f2e00730765087735c8f9c6c6c5ea6
https://doi.org/10.1007/978-1-4614-9545-1_2
https://doi.org/10.1007/978-1-4614-9545-1_2
Publikováno v:
Molecular Cancer Research. 14:A61-A61
We will describe recent progress in understanding the role of cancer metabolic remodeling in determining the response of tumors and tumor cells to a novel, first-in-class clinical agent class selectively targeting cancer cell mitochondrial metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e1609aafc527bdc923048065ad4f84
https://doi.org/10.1158/1557-3125.metca15-a61
https://doi.org/10.1158/1557-3125.metca15-a61
Autor:
Zuzana Zachar, Paul M. Bingham
Publikováno v:
Dehydrogenases
© 2012 Bingham and Zachar, licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a784b8b8e64cbafeaf5844c16ad1562
http://www.intechopen.com/articles/show/title/the-pyruvate-dehydrogenase-complex-in-cancer-implications-for-the-transformed-state-and-cancer-chemo
http://www.intechopen.com/articles/show/title/the-pyruvate-dehydrogenase-complex-in-cancer-implications-for-the-transformed-state-and-cancer-chemo
Publikováno v:
Scopus-Elsevier
The Drosophila suppressor-of-white-apricot [su(wa)] protein regulates/modulates at least two somatic RNA processing events. It is a potent regulator of its own expression. We report here new studies of this autoregulatory circuit. Among other things,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9444b4bf876f8fe5e3c620b5bc9bde
https://doi.org/10.1093/genetics/137.1.139
https://doi.org/10.1093/genetics/137.1.139